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Comparative characteristics of iron deficiency states In children of Nepal and the North Caucasus, taking into account the adherence to traditional nutrition and vegetarianism
Iron deficiency conditions are widespread diseases. Nepal, as well as the North Caucasus, refer to mountainous territories in connection with which the question of the influence of the geographic climate area of accommodation on the frequency of iron deficiency states is. The purpose of the study: to determine the frequency of iron deficiency states in children of one year of life in Nepal and...

Complex approach to the treatment of phegmon and compartment syndrome of the upper limb
The paper presents the results of diagnosis and treatment of patients with phlegmon of the upper limb (shoulder and forearm) against the background of compartment syndrome. The study included 134 patients with intermuscular phlegmon of the shoulder and forearm, aged 18 to 75 years. The subjects were divided into two groups: I (the control group, n=62) and II (the main group, n=72). All subjects...

About the necessity of standardization of approaches to treatment and rehabilitation of patients with temporomandibular joint pathology in the institutions with different forms of property
The analysis of 365 cases of treatment and rehabilitation of 219 men and 146 women (aged 18–72 years) with dysfunction of temporomandibular joint (TMJ), temporomandibular arthrosis, arthrosis-arthritis and painful musculo-articular dysfunction at inpatient (96 cases) and out-patient (269 cases) clinics with different forms of ownership has been carried out. In all health facilities there...

Age - and gender -related characteristics of child morbidity
The article is devoted to the problem of child morbidity in a megalopolis. Using the morbidity indicator makes it possible to analyze morbidity levels in different age and gender groups. This, in turn, allows to obtain more objective data compared to assessing the morbidity according to official statistics. The publication presents the results of the morbidity study classifying diseases in the...

Age plastici ty of the neurons nitrergic subpopulations in the olfactory bulbs of rat
In immunohistochemical studies, n-NOS-positivity is detected in the bodies and processes of neurons. In the rat’s olfactory bulb, there are three subpopulations of n-NOS-positive neurons with different enzyme activity levels and different dynamics of age transformations. The heterogeneous enzyme activity is due to the different functions of neurons. That must be taken into account when...

An integrated approach to the treatment of complicated forms of hiatal hernia taking into account the patient’s individual features
We describe the treatment of 163 patients with complicated hiatal hernia. The research objective was to increase efficiency of treatment of patients with complicated forms of hiatal hernia using an integrated approach that takes into account specific features of the patient. Patients were divided according to body type. The integrated approach to the treatment of complicated forms of hiatal...

Analysis of risk factors for HIV-infection in females
The aim of the study was to assess the prevalence of HIV infection risk factors in women in the Republic of Tatarstan. Anonymous questioning of 208 women with HIV infection was conducted. The majority of those surveyed had an education level higher than average, a stable job, assess their financial situation as an average or above average, profess Christianity or Islam, were in an official or...

Anatomical and topographical features of temporomandibular joints in various types of mandibular arches
According to the results of the study of cone-beam computer tomograms and plaster models of the jaws of 151 people with physiological occlusion, with a full set of permanent teeth, at the absence of signs of pathology of the maxillofacial region, morphometric parameters of the head and lower dental arches, as well as the inter-articular angle were calculated. Depending on the gnatical, dental...

Anatomical variability of kidney arterial vasculature based on zonal and segmental topography
The analysis of anatomical variability of the intraorgan arterial bed of the kidney (IABK), taking into account the zonal and segmental topography, was carried out. The arterial vasculature was visualized using corrosive casting. In this study, 116 vascular casts were included. We determined the number of arterial segments (AS) in the kidney hilum, their topography, variants of renal artery (RA)...

Application of the integral complications severity index for optimization of surgical treatment for acute cholecystitis of mild and moderate severity
In this study, a multicenter retrospective cohort study was conducted, which included all 754 patients operated on in 8 hospitals in Moscow, Yekaterinburg, Volgograd and Kislovodsk for one year for acute cholecystitis. To assess the results of surgical treatment, the classification of the severity of complications – Accordion was modified by adding a score to assess the severity of...

Bone marrow and adipose-derived rat mesenchymal stem cells for recellularization of biological matrices
The morphological features, proliferative activity and flexibility of rat mesenchymal multipotent stem cells (MSC) bonemarrow derived and isolated from the adipose tissue stromal-vascular fraction were evaluated. MMSCs were verified by the negative CD 34 and the positive CD 90, and by induced differentiation. Cells proliferative activity was evaluated by Ki-67 cytochemical staining with...

Clinical and computer-tomographic diagnostics of the individual position of medial cutters in people with physiological occlusion
Based on the results of studying the gypsum models of the jaws, teleroentgenograms and cone-beam computer tomograms of 109 patients with physiological occlusion and a full set of permanent teeth, the clinical and radiological inclination values of the central incisors of the upper and lower jaw were calculated, as well as the parameters of the intercutaneous angle. The patients, depending on the...

Comparative analyses of complications development during sinus lift surgery
The article presents an analysis of the frequency and severity of complications that occur during sinus lifting surgery using piezosurgical equipment and rotary instruments. At the first stage of the study, a prospective survey of practicing specialists was performed. At the second stage, the frequency of complications was studied. The division into study groups was carried out taking into...

Comparative analysis of treatment approaches to chronic periodontitis using antimicrobial photodynamic therapy (in one visit) and Calasept
88 root canals of 65 patients were examined and treated. It was established that antimicrobial photodynamic therapy leads to the reduction of the amount of clinical cases associated with pain response after one-stage treatment of chronic periodontitis in comparison with the results of calcium hydroxide application. Application of laser radiation for preparing the root canal for obturation allows...

Comparative characteristic of the common lumen of anterior interventricular branch of the left coronary artery in norm and myocardial infarction
Subepicardial branchings of anterior interventricular branch of left coronary artery were studied in 40 hearts as well as 40 lifetime coronarographies of humans in the second period of mature age and elderly with left, right, and uniform variants of coronary branching in normal and myocardial infarction. A comparative characteristic of the values of the total cross-sectional area of the anterior...

Complex treatment of gluteal phlegmon and compartment syndrome
In the study was to optimize the treatment strategy in patients with gluteal phlegmons through identifying of factors contributing to the disease. Analysis of the biomechanical properties of the fascial structures of the gluteal region was performed on 40 corpses using an original technique (patent for invention № 2271740). The clinical part of the study – analysis of the treatment...

Connection linear parameters of liver with individual somatotype
Development of the regulatory database of liver linear parameters due to spiral computed tomography (SCT) in view of the individual constitution will contribute to the accuracy of data interpretation. 193 persons 16 – 35 years of age were examined using abdominal SKT. Somatotype was determined by the method of L. Rees – H. J. Eysenck (1945). According to the somatotype surveyed were...

Content of B- and T-cells in the spleen of patients with aplastic anemia
Using histological, immunohistochemical (IHC) and morphometric methods, B- and T-cells, we studied the spleens of 30 patients with aplastic anemia (AA). The median age is 21.0 (18.5; 38.5) years. The control group consisted of 20 persons who died suddenly and who did not have a history of blood diseases. In the histological material of the spleens, with IHC staining and morphometry, the relative...

Dental oncological vigilance in the Stavropol Region: systemic issues and progress vectors
The article presents an analysis of the situation involving oral cavity malignant neoplasms (MN) in the Stavropol Region in the context of dental oncological vigilance. The relevance of the issue is due to the steady increase in the number of patients suffering from oral cancer in the Russian Federation, as well as to the need for its early detection during dental visits. The aim of the study is...

Dependence of the size and number of silver nanoparticles on the ligand concentration in the reaction system
Technologies focusing on the synthesis of silver nanoparticles (AgNPs) are of high relevance within experimental and practical medicine, which can be accounted for by their antibacterial, antiviral, and fungicidal properties, as well as by their capacity to reveal particular antitumor activity, constitute a substantial part of several medical devices and diagnostic consumables. This study shows...

Detoxification process of patients with obstructive jaundice of various genesis
The aim of the study was to improve the results of treatment of patients with obstructive jaundice. A new method of detoxification of patients, ta-king into account all the measures required to determine the exact amount of injectable solutions amid of bile passage restoration. Volume of infusion therapy was directly dependent on the osmolarity of plasma, bilirubin and body weight. Comparative...

Dismicroelementoses in children with urticaria of various degrees of severity
The features of the microelement status of children with acute urticaria based on the determination of the microelements in the hair have been studied. 40 patients with acute urticaria aged 2–12 years were examined. In all children with mild urticaria dysmicroelementosis was characterized by an absolute decrease in the content of zinc and nickel, and in patients with a moderate-to-severe...

Diverticular disease of the collon: clinic -instrumental and immunomorphological parallels
Diverticular colon disease, taking into account the increase in the proportion of older people in the total population of the planet, is one of the most important problems of modern health care, due to the need for constant monitoring of patients due to the possible development of complications such as diverticulitis, perforation, bleeding and malignancy. From these positions, it becomes relevant...

Diverticule of the common hepatic duct in an infant
The frequency of cystic transformation of the bile ducts is 1:100 000–150000 people and in 97 % of cases there are type I cysts on Todani. Type II cysts account for less than 2 %. The article presents a clinical observation of a 5-month-old patient with a diverticulum of the common hepatic duct. The diverticulum was located at the confluence of the right and left hepatic ducts. The clinical...

Effect of combined oral contraceptives conaining drospirenone + ethinylestradiol on the mammary gland condition in women of reproductive age
Drospirenone, as a part of combined oral contraceptives, has an antiproliferative effect on hyperplastic processes in the organs of the female reproductive system. Individual selection of COCs taking into account the dose and properties of the gestagenic and estrogenic components allows, with contraceptive and non-contraceptive purposes, to prescribe it to women of reproductive age. Intake of COC...

Effect of microbial landscape on the character of antibacterial therapy in newborns with necrotizing enterocolitis
A clinical and microbiological assessment of the treatment of 67 newborns operated on for progressive necrotizing enterocolitis (NEC) was carried out. Taking into account the results obtained, initial antibiotic therapy (ABT) was corrected, including meropenem and vancomycin (70.7 %): vancomycin was replaced with linezolid, and meropenem – with ceftazidime/cefepime. Ciprofloxacin (9.8 %)...

Epigenetic mechanisms in epilepsy. Paradigm shift in seizure prevention and treatment
The main epigenetic approaches for understanding the pathogenesis of epileptic seizures are considered, the leading components of the formation of convulsive activity in the neurons of the cerebral cortex are given, taking into account changes in DNA methylation systems, modification of histones and non-coding RNAs. The possibility of pathogenetically justified optimization of the regulation of...

Esophagus decellularization protocols in Macaca mulatta model
Decellularization is used in biomedical engineering to isolate the extracellular matrix (ECM) from its inhabiting cells, preserving the ECM of the scaffold, which could be used for biological non-immunogenic and non-toxic scaffolds obtainment for creation of full-fledged organs and tissues. Taking into account the importance of transferring results into clinic, the model of the non-human primates...

Evaluation of perspective of propiotics in cjmplex therpy of neurastenia
The prospects of the «Bac-Set Forte» probiotic in the complex treatment of neurasthenia taking into account neuro-immuno-endocrine changes were evaluated. The results confirmed the effectiveness of the «Bac-Set Forte» probiotic preparation as an additional vector of standard therapy for...

Evaluation of short-term outcomes in preterm infants with necrotizing enterocolitis
The work assessed the impact of the principles of open resuscitation on the results of the treatment of premature infants with NEC. The type of organization of the ICU (open or limited access) did not affect the daily and 7-day mortality. The previous severity of the NEC condition and the nature of the surgical intervention were of primary importance. Significant differences were noted in terms...

Experience of detection of HER 2 status of circulating tumor cells in the peripheral blood of patients with HER 2-negative locally advanced breast cancer
The study of biological characteristics of CTCs, in contrast to other malignant cells in the primary tumor, suggests new tumor markers with a high predictive value. HER2 overexpression in the tumor leads to enhanced proliferation and angiogenesis and apoptosis regulation disorders. HER2 overexpression in BC was confirmed to be associated with a more aggressive disease course, increased metastatic...

Features of antibiotic resistance in Stavropol region
The paper considers the problem of antibiotic resistance (AR) in Russia, taking into account the regional peculiarities of the Stavropol Territory. The article presents the results of monitoring of antibiotic resistance in Stavropol Territory over the past ten years based on epidemiological studies in medical institutions. The importance of regional analysis for understanding the microbiological...

Features of cardiac remodeling in patients with frequent exacerbations of severe COPD and in its combination with arterial hypertension
Determination of ultrasound markers of cardiac remodeling in patients with severe chronic obstructive pulmonary disease (COPD) was provided, taking into account the characteristics of its course and comorbidity in arterial hypertension (AH). 114 patients with severe COPD were examined divided into 4 groups, taking into account the frequency of exacerbations, the presence of hypertension. The...

Features of speech disorders of preschool children of urban and rural areas in the European North of Russia
The features of the speech development of pre-school children living in the regional center, village and rural areas of Northern European Russia are studied. The infants and young children living in ur-ban and township areas, had disturbances of sound pronunciation, phonemic perception at preservation of all the other components of speech, in the coun-tryside – speech motor skills suffered...

Forecasting and prevention of postoperative complications in patients with uncomplicated pilonidal sinus
This item offers a view of the outcomes of examination and treatment of 118 patients suffering from pilonidal sinus (PS). The patients were divided into two groups. In the control group, the patients underwent excision of the PS followed with suturing of the postoperative wound with Donati stitches. The main group were 67 (56.7 %) patients, whose treatment implied taking into account the...

Genetic characteristics of children with celiac disease living in the south of Russia
HLA-typing was performed on 110 children with celiac disease living in the South of Russia to identify HLA-DQ haplotypes. The diagnosis of celiac disease was established for all children following the criteria ESPGHAN 1999 and 2012. There were 50 (45.5 %) boys and 60 (54.5 %) girls. HLA-positive patients accounted for 108 (98.2 %) cases. The most common allele was DQ2 – 87 (79.1 %)...

Heredity connective tissue diseases and student’s medical examination: aspects of screening diagnosis
Objective – to evaluate the diagnostic potential of the modified mini-list of external stigma signs for the needs of the student health examination. It was studied a total of 100 students. Identification of dysplastic phenotypes was carried out in accordance with Russian recommendations, of cardiovascular syndromes – with personal questionnaires. The amount of phenotypic traits was...

HIGH-throughput sequencing and targeted therapy in metachronous acute myeloid leukemia: application experience
An analysis of a case of diagnosis and treatment of acute myeloid leukemia (AML) using the high-throughput sequencing method in a mature patient is presented. The debut of AML (morphological variant – acute promyelocytic leukemia, APL) manifested in patient K., 53 years. Taking into account the AML variant, program chemotherapy with all-trans-retinoic acid (ATRA) in combination with...

Hygienic assessment of nutrition of children in educational institutions of the ci ty of Stavropol considering different methods of cooking
The article presents the analysis of the actual nutrition of children on the macro- and micronutrient composition of 12-day diets of pupils of educational institutions of Stavropol aged 11–14 years. Schools were selected taking into account the technology of cooking dishes on the traditional and the modern new technological equipment. Research results show that the use of new technologies...

Importance of actual nutrition in the prevention of non-infectious diseases
Healthy nutrition is a key factor in reducing the risk of chronic non-infectious disease development and progression. In the present review, we assessed the results of epidemiological and clinical studies reporting participants’ nutritional features including unbalanced rations, excessive caloric intake, and a lack of food intake variety, as well as differences between male and female...

Individual and typological features of the physical status and component composition of the body of elderly men with sarcopenia combined with concomitant diseases
The study included 198 men aged 61 to 75 suffering from sarcopenia (group I) and 48 men with no history of sarcopenia (group II). The study showed that the representatives of the II group are characterized by a significantly higher value of body weight and BMI (by 1.09 times and 1.1 times, respectively), compared with the I group (P<0.05). The number of hypersthenics among men of group II...

Individual position of cutting teeth by a physiological occlusion of the permanent teeth in people with different types of facial skeleton structure
This article considers the significances of angles of inclination of central cutting teeth of a mandible and a maxilla and their correlation with a size of interincisal angle in people, who have three types of a facial skeleton (mesofacial, dolihofacial and brahifacial) at physiologic occlusion of permanent teeth. There are a lot of different programmed braces today, each of these presents its...

Influence of clinical and demographic characteristics and cognitive functions on working capacity in remission of recurrent depression
The study aims to estimate the effect of sociodemographic and cognitive features on presenteeism, absenteeism and working capacity in patients with recurrent depressive disorder in remission state. Thirty patients were recruited and 53.3 % of them met criteria of complete remission. The disability depends on pessimistic thoughts, deficits in attention and resistance to non-affective interference....

International declaration of adherence to treatment 2023 («Omsk declaration»): presentation for Russian readers
The article covers the main principles and approaches that was formed in the international declaration of commitment to treatment. Along with the publication of the declaration text, its main provisions are commented on. The importance of assessing the potential adherence to treatment and a comprehensive assessment of adherence is highlighted. It is proposed to consider the adherence to treatment...

Leprosy in the family: clinical observation
Hereditary predisposition and long-term family contact with the source of the disease are the key factors in leprosy process development. The described clinical case confirms the need of thorough study of the epidemiological history, identification and examination of persons in contact with leprosy patients, long-term follow-up and regular examination, as well as knowledge of the clinical...

Medical -biological aspects of recovery in professional and amateur sports
The review considers the basic principles of recovery after exercise in professional and amateur sports. Restoration of the body is the return of physical parameters to the initial values, increasing the adaptive capacity after performing physical work. Proper recovery after exercise helps avoid problems such as physical fatigue, lack of nutrient intake, injuries of various severity, dehydration...

Modern features of the course of syphilis (clinical observation)
The incidence of syphilis in Russia remains high, while increasing daily for a number of reasons, all this entailing a need for various medical professionals to be able to recognize this disease. According to WHO, over 50 million people worldwide contract syphilis every year. As the World Health Organization reports, one of the important features of the epidemiology and clinic of syphilis is its...

Monitoring survey of antibiotic sensitivity in child urinary system infectious agents (experience in Stavropol)
The population subject to the study included 220 children aged 1 month – 5 years, with acute community acquired infections of the upper and lower urinary tract. As the data obtained showed, the major agents causing community acquired UTI in the first 5 years of age were bacteria belonging to the Enterobacteriaceae family, E. coli predominantly. The major features in the structure of the...

Morphometric characteristics of the middle cranial fossa communication in various forms of the cerebral skull
Access to the middle cranial fossa is nowadays seen as one of the most effective in surgery of the skull base. At the same time, from the anatomical stance, it remains one of the most difficult areas. The aim of this work is to study the topographic features and morphometric specifics of the foramina in the middle cranial fossa at various shapes of the cerebral skull. The parameters were measured...

Multilevel analysis of regulatory mechanism disorders as a principle of choice for individual antihypertensive therapy in patients with hypertension (Part II). Optimization of antihypertensive therapy choice taking into account the multilevel analysis of violations in regulatory mechanisms of arterial blood
Aim: optimization of the individual antihypertensive therapy (AHT) choice in patients with hypertension (H) taking into account the violation analysis of arterial blood pressure (AP) regulation system. This study has included 277 patients with hypertension degree II at the age of 58.6±6.4 years. As a form of monotherapy it was administered: nebivolol, lisinopril, losartan, indapamid...

Muscle activity in patients with dysfunction of the tismatmouralmality: the role of unifferentiated connective tissue diplasion
Patients 2 groups: group 1 included 28 patients with the syndrome of pain dysfunction of TMJ and signs of NDST; group 2 consisted of 32 people with the syndrome of pain dysfunction of TMJ, with no signs of NDCT. Registration of BEA of masticatory and temporal muscles was performed by the method of global electromyography «Neuro-EMG-Micro-2» using functional samples: chewing and...

Myocardial micro -alternation index: influence of age, gender and pre valence of normal values in screening of the population
Myocardial micro-alternation index (IMM) is one of the characteristics of the ECG dispersion mapping (DM) which is widely used for screening of the population.We studied the relationship between IMM, age and gender. We also investigated the prevalence of different IMM ranges: normal (<15 %, 15–21 % – boundary, >21 % – pathological) in visitors of the health centers...

Neurotoxicity caused by anesthetics in pediatric anesthesia
In a review of the current literature assesses the recently discovered phenomenon and the toxicity of anesthetics in the developing child brain. The ways of diagnostics of morphological and functional abnormalities of brain activity in children. Provides indisputable data on the possibility of this type of interactions taking into account the mechanism of action of anesthetics. Comparative...

Orthotopic grafts of human malignant gliomas: history, technologies, achievements and problems
Problems of the development of human malignant gliomas` orthotopic grafts for in vivo studies, taking into account their significance for fundamental and clinical oncology, the degree to which growth characteristics and morphogenesis correspond to the characteristics of the initial tumors are discussed. Main results of previous experimental research providing the possibilities of studying of...

Particularity of the clinical course and quality of life of patients with chronic obstructive pulmonary disease on the background of the metabolic syndrome
In 100 patients with chronic obstructive pulmonary disease (COPD), the features of the clinical and functional status and quality of life were studied depending on the presence or absence of the metabolic syndrome. Metabolic syndrome was diagnosed in 70 % of patients. In patients with COPD and metabolic syndrome, the frequency of exacerbations and hospitalizations, the severity of dyspnoea, cough...

Peculiarities of cerebral cortex synthetic activity at determination of adaptive ability in patients with completely absent dentition
The article presents the results of determining the synthetic activity of the cerebral cortex in patients of elderly and senile age with completely absent dentition. To calculate the adaptability to prostheses, the degree of atrophy of the edentulous alveolar processes, their ratio and the peculiarities of patients’ oral stereognosia were taken into account. The proposed clinical diagnostic...

Peculiarities of the orientation of the occlusion plane in people with different types of the gnatic part of the face
On profile teleroentgenograms of the head, obtained from 74 people of the first period of adulthood with physiological occlusion and normoinclination of the gnathic part of the face, the orientation of the following cephalometric planes was analyzed: plane of the skull base (N-Se); Frankfurt plane (Or-Po); the plane of the base of the upper jaw (Sna-Snp); occlusal plane (OcP); the plane of the...

PEP-36E and ABP-9L cationic peptides stability evaluation in blood serum and under thermal stress in vitro
The study aimed to evaluate the impact that blood serum and heating have on the in vitro antibacterial activity of the PEP-36E and ABP-9L cationic peptides. The activity was identified through measuring the minimum inhibitory concentration (MIC) using the serial dilution method against a clinical isolate of Escherichia coli. The control group had the MIC values at 12.5 and 10 μg/mL...

Personalized surgery in children with temporal lobe epilepsy
Eighty patients with symptomatic drug-resistant temporal epilepsy aged 2–17 years were operated on from 2011 to 2016, the factors that influenced the outcome of surgical treatment were studied. Favorable prognostic factors for the effectiveness of surgical treatment in the long-term period were: male sex (p<0.01), children older than seven years (p<0.01), disease duration less...

Pharmacokinetics of dornase alpha in cystic fibrosis in childhood and adolescence
A study of the nuclease activity in the plasma of children and adolescents with cystic fibrosis (CF) during therapy with Dornase alpha was carried out. The level of nuclease activity was measured in 35 patients after inhalation of Dornase alpha. An increase in the level of nuclease activity of blood plasma after inhalation of Dornase alpha by patients with cystic fibrosis was obtained. High...

Planning and evaluation of bioequivalence study of HMG-CoA reductase inhibito
The results of a retrospective analysis are presented to determine the coefficients of intraindividual variability and the unification of approaches to the planning and evaluation of bioequivalence studies of HMG-CoA reductase inhibitors. Atorvastatin, simvastatin and lovastatin have demonstrated high intraindividual variability both in the parent compound and in the active metabolite in many...

Rare clinical case – life-time diagnosis of the cardiac angiosarcoma
The article describes a clinical case of cardiac angiosarcoma in a 25-year-old woman at its onset, discusses the challengers treatment approach choice, taking into account the patient’s condition. In domestic and foreign literature there are no descriptions of in vivo diagnosis of angiosarcomas surrounding all parts of the heart, as in this clinical case....

Rectovaginal fistulas. Is there an optimal method of surgical treatment?
Rectovaginal fistulas belong to a rather rare pathology, accounting for about 3 % of all coloproctological diseases and 5 % of all rectal fistulas. This pathology causes significant physical and psychosocial stress in patients. Currently, more than 100 modifications of operations are described in Russian and foreign literature, but the number of relapses remains at a high level. The choice of the...

Review of medical collections of Stavropol city museums
The article presents a brief description of medical collections of Stavropol museums. Materials of museum collections were studied: official records and museum objects directly. Stavropol State Museum - Reserve owns the most valuable materials on medical subjects. A museum complex of Stavropol Medical University has the vastest material. Hematology museum of the North Caucasus Federal University...

Risk factors and prognosis prevention reflux gastritis following gastric resection
The possible causes of reflux gastritis after gastrectomy for peptic ulcer disease were studied. Various modifications of gastric resection, as well as risk factors for reflux gastritis in the preoperative period were considered in 32 patients. The susceptibility to the development of reflux gastritis, taking into account the criteria that influence the development of this disease: data of...

Risk factors of brain vascular pathology in patients with hereditary dysplasia of connective tissue
The paper presents an analysis of risk factors for brain vascular pathology in patients with hereditary connective tissue dysplasia. A significance of morphological changes in brain vessels, as well as disturbed central and cerebral hemodynamics, and coagulopathies in Marfan and Ehlers-Danlos syndromes, as well as in fibromuscular dysplasia are shown. Management of the subjects with hereditary...

Role of cytokines in the formation of immunological microenvironment in low-grade brain gliomas, their significance for diagnosis and immunotherapy
Glial tumors account for 35.5 % of all CNS tumors, and 54 % of glial tumors are glioblastomas (GB). The median survival in GB is about 15 months. Important prognostic criteria, along with histological characteristics of the tumor, include molecular genetic aberrations. Based on the presence of IDH gene mutation, was formulated the concept of «secondary glioblastoma», and proved that...

Role of fetus sex in expression of angiogenic factors and supporting of citokine balance in maternal organism in physiological pregnancy and in placentary insufficiency
Changes in the expression of bioactive peptides contribute to the formation of many complications of gestation. The aim of the research was to study the effect of fetal sex on the production of angiogenic factors and cytokines in women during physiological and complicated pregnancy. In 172 women with physiological pregnancies and 188 with placental insufficiency, the level of angiogenic factors...

Role of genetic factors in therapy with indirect anticoagulants in ethnic groups of Stavropol Region
The study focused on specific issues about intake of indirect anticoagulants and the impact of the drug response genetic characteristics in representatives of the three ethnic groups residing in the Stavropol Region – Slavs, Armenians, and Karachais. The results showed that reaching the target value of INR inArmenians took a lower daily dose of Warfarin – 3.9 mg, while in the...

Rotavirus and norovirus infection in adult
Authors analyzed the medical records of 96 patients. The first group – 78 patients with rotavirus infection (mean age 47.9±5.8 years), the second – 18 patients with norovirus infection (mean age 49.1±7.8 years). Rotavirus antigen was detected in the feces by ELISA, noroviruses and rotaviruses RNA was detected in the feces. In adults, rotavirus infection occurs mainly in...

Sanatorium-spa treatment of patients with arterial hypertension: selection of tactics by mathematical modeling
The article substantiates the relevance of the use of mathematical modeling in choosing the method of sanatorium treatment. The number of patients who participated in the study is 72 (30 men and 42 women) aged 51.3±3.1 years (from 20 to 74 years). Arterial hypertension was observed in 1–2 stages, 1st degree, low, medium and high risk of complications. The results of therapy are...

Screening of newborns in Stavropol region for inborn immunity issues
This study presents a review of the results obtained through expanded screening of newborns in Stavropol Region embracing a period of over 2.5 years, during which abnormal biomarker levels were detected in 25 out of 61391 newborns. Molecular genetic testing identified congenital immune disorders in 8 infants, indicating an overall prevalence rate of 1:7674 in Stavropol Region. The frequency of...

Semiquantitative evaluation of caries microflora in patients with dental and alveolar abnormalities and different severity of morphofunctional disturbances
The content of caries bacteria – Streptococcus mutans – in mixed saliva and dental plaque was evaluated through semiquantitative microbiological investigation in children aged 12–15 years with dental and alveolar anomalies. Controlled biological criteria for the risk of development and growth of the intensity of caries: Streptococcus mutans concentration of 1×106 CFU/m...

Specific features of mitochondrial biogenesis of monocytes during differentiation into macrophages
The item offers a view of the analysis of the orientation of mitochondrial metabolic processes with manifestations at both the biochemical and clinical levels, which allowed separating them based on the fundamental predominance of exo- or endothermic reactions. During that, the functional features of M1–Mφ and M2–Mφ macrophages were taken into account, which feature some...

Stroke epidemiology indicators in Stavropol (according to population -based register data in 2009–2014)
The incidence mortality rate of stroke among men and women had been studied in Stavropol city during 2009– 2014 years. The research was performed as population-based register with an application of MONICA international study (1985–1995) protocol. During 2009–2014 an estimation of acute stroke cases (28 days from symptoms onset) in the Promyshlenniy district of Stavropol city was...

Students’ health resources screening and formation of intrauniversity preventive environment: clinical, educational, instructional and pedogogical aspects
Screening of 1350 students of STSMU show risk factors of presence of socially significant diseases at sufficient frequent intervals, starting with the 1st year of study .It is noted that these risk factors are mostly gender and are more demonstrated among young men. Also the differences are discovered depending on the faculty of education - the cases of high blood pressure in young men were more...

Surgical revascularization of the brain in acute period of ischemic stroke
Vascular diseases of the brain as the cause of death are in the third place after ischemic heart disease and cancer, accounting from 11 to 15 % [8]. Problems of surgical revascularization of the brain in acute period of ischemic stroke need studying and discussion to make informed tactical...

Surgical topography of the arteries of the isthmus of the pancreas
The possibility of optimization of surgical interventions on the pancreas, taking into account the topography of arterial vessels, is considered. 38 pancreas were studied by the method of anatomical preparation. The topography of arterial vessels was assessed on a transverse section of the organ in the isthmus region. The topography of the main arteries of the isthmus of the pancreas is...

Systemic inflammation in patients with community-acquired pneumonia combined with subclinical hypothyroidism
In the study was investigation the factors of systemic inflammation in patients with community-acquired pneumonia combined with subclinical hypothyroidism (SH). One hundred thirty four people aged 37.4±3.3 years were observed, including 32 with CAP combined with SH (the main group), 68 with CAP without SH (the comparison group) and 34 healthy individuals. In all patients with CAP, along...

The differentiated approach to the choice of surgical correction techique in the cases of auricle partial defects
Based on the experience of 14 cases of the auricle partial defect correction the different surgical approaches and techniques are presented and considered. It is concluded that in order to achieve a satisfactory outcomes of surgery requires careful preoperative analysis of the defect, compiling individual plan of the operation, a differentiated approach to it, depending on the location of the...

The fat hepatosis and clinical-metabolic risk factors in adolescent with obesity
The aim of the study is to determine the contribution of the main clinical and metabolic risk factors of the fatty hepatosis development and its role in the progression of obesity in adolescent. The study included 84 adolescent (12–17 years old) with simple (exogenous-constitutional) obesity using a random sample. It was revealed that the highly sensitive (0.6 and more) risk factors for the...

The features of spectrum and frequency of CFTR gene mutations in populations of Southern Russia and Northern Caucasus
The spectra and frequencies of CFTR pathogenic variants in CF patients from the Southern Federal District and North Caucasus regions were compared. 299 unrelated CF patients from the southern Russia and 165 from the North Caucasian Federal District were tested. Russians accounted for about 80 % of CF patients in the Southern Federal District. Variants F508del (58 %), CFTRdele2,3 (6 %) were...

The importance of a comprehensive assessment of fetometry and anthropometry in a pregnant woman for predicting the weight of a newborn
Accurate prenatal fetal weight estimation is hindered by universal formulas that do not account for regional and maternal parameters, leading to errors in various populations. This study analyzed 5161 cases of term singleton pregnancies in the Kirov region (2018–2023): regional percentile curves for femur length (FL) and abdominal circumference (AC) were constructed using ultrasound data...

The interconnection acid-base blood balance and dysbiosis in children with chronic constipation
Interconnection of correlations of the acid-base blood balance with dysbiosis in 121 children with chronic constipation was found in the study. Metabolic acidosis is revealed with a high lactate concentration, emaciation of the organism buffer systems on the lowering background of main blood electrolytes and dehydration. And in its turn it takes place on the marked translocation of the intestinal...

The pathophysiological bases of contemporary pharmacotherapy
The pathophysiological aspects of contemporary approaches to the formation of clinical thinking in the area of planning the pharmacotherapeutic technologies are discussed. The role of the knowledge of etiology, pathogenesis, outcomes of diseases in pharmacotherapy planning, taking into account the individual mechanisms of reactivity, evidence based medicine in the prognostication of drugs effects...

The place of evaluation vascular rigidity in process of student’s health screening
Cardio-ankle vascular index (CAVI) has a high prognostic significance for development of cardiovascular events. However, its values in the young population are quite vague still. In 149 students (55 boys, 94 girls) from 17 to 22 years old were assessed the vascular wall by indicators of CAVI using the device Vasera VS-1500 (Fukuda Denshi, Japan). Percentile analysis showed that the 95th...

The postoperative recurrences of congenital diasphragmatic hernia
Purpose: Objective: to exclude the potential recurrences of congenital diaphragmatic hernia (CDH) using an effective method of sewing the diaphragmal defect. Three cases of recurrence of the left-sided CDH, developed in the group of 127 newborns, being operated from 1982 till 2012, were analyzed in detail. The technique of diaphragmatic defect suturing is given in detail, taking into account the...

The predictors of central nervous system damage in newborns with asphyxia
The clinical and biochemical study of 50 full-term newborns who had suffered asphyxia during labor was carried out. The control group consisted of 91 newborns without asphyxia. It was determined that the children with symptoms of hypoxic brain damage with the history of asphyxia had high concentrations of interleukins (IL): IL-1β, IL-4, IL-6, IL-8, tumor necrosis factor-α...

Treatment management based on adherence: patient recommendation algorithms. Cross-disciplinary guidelines
The algorithms (sample templates) of recommendations for patients, which are an integral part of adherence-based treatment management technologies, were developed by an interdisciplinary Working Group coordinated by the Treatment Adherence Section of the Russian Scientific Medical Society of Physicians. The Working Group includes opinion leaders and experts in the therapeutic, gastroenterology...

Treatment of patients with uncomplicated chronic form of pilonidal sinus inflammation
The article contains the results of the surgical treatment of 96 patients with simple chronic inflammation of the pilonidal sinuses. The control group consisted of 47 patients who underwent surgical treatment using «pilonidal sinus removal with fixation of the edges of the wound at the bottom, taking into account the height of the buttocks». The main group consisted of 49 patients who...

Undifferentiated pleomorphic sarcoma of the larynx. Сinical case
Head and neck cancer is a heterogeneous group of malignant neoplasms that develop in various anatomical areas: the nasal cavity, paranasal sinuses, oral cavity, oropharynx, laryngopharynx, larynx, nasopharynx and salivary glands. According to WHO, tumors of this localization account for about 10–12 % of all malignant neoplasms in adults. More than 90 % of them are squamous cell carcinoma...

Variability of odontometric indices in the aspect of sexual dimorphism
Biometric examinations of jaw stone models and tomography images of 310 people (both genders) in their first adulthood stage with permanent teeth physiological occlusion were used to study the morphometric parameters of dental types and dental arches gnathic types in each patient. Odontometric procedure included evaluation of the crowns mesial-distal width involving the calculation of the...

Vitamin D levels in newborns children of Stavropol Region
Vitamin D has a wide range of biological effects. There is evidence suggesting an important role of vitamin D in women’s reproductive health, yet there has been no research focusing on newborns in South Russia. The purpose of this current study was to analyze the levels of vitamin D in newborns in the Stavropol Region. The clinical, anamnestic, and laboratory examination involved 60...