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https://doi.org/10.14300/mnnc.2015.10039

Role of genetic factors in therapy with indirect anticoagulants in ethnic groups of Stavropol Region

[Clinical Pharmacology]
Vladimir Baturin; Anna Tsarukyan;

The study focused on specific issues about intake of indirect anticoagulants and the impact of the drug response genetic characteristics in representatives of the three ethnic groups residing in the Stavropol Region – Slavs, Armenians, and Karachais. The results showed that reaching the target value of INR inArmenians took a lower daily dose of Warfarin – 3.9 mg, while in the Karachais and in the Slavs this dosage was 5.1 mg and 5.2 mg, respectively. Of the patients who reached the target level of INR Armenians were prevailing – 57%, while Slavs accounted for 31.7% and Karachais – 33.3%; the number of the patients with a high level of INR (>3) was highest among Armenians – 25.7% (Slavs – 18.3%, Karachais – 11.1%). According to the results of genotyping the maximum frequency of the “slow metabolizers” was detected among the Armenians – 52.6%. Based on the outcomes obtained, identification of CYP2C9 genotypes is recommended to be introduced into the list of compulsory medical studies to be performed in clinical practice.

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Keywords: Warfarin, CYP2C9, ethnic-bound issues, biotransformation, cytochrome P-450