Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 865 2352511, +7 865 2353229.


Effect of microbial landscape on the character of antibacterial therapy in newborns with necrotizing enterocolitis

Izabella Mikhailovna Veshkurtseva; Mikhail Aksel’rov; Sergey Minaev; Svetlana Suprunec; Viktoria Emel’janova; Svetlana N. Gordiychuk,; Tatiana Sergienko; Alexander Leonidovich Barinov; Evgeniy Kolesnikov;

A clinical and microbiological assessment of the treatment of 67 newborns operated on for progressive necrotizing enterocolitis (NEC) was carried out. Taking into account the results obtained, initial antibiotic therapy (ABT) was corrected, including meropenem and vancomycin (70.7 %): vancomycin was replaced with linezolid, and meropenem – with ceftazidime/cefepime. Ciprofloxacin (9.8 %) was used to identify resistant Gr– microflora. When the non-fermenting microorganism S. maltophilia was inoculated, co-trimoxazole (6.4 %) was prescribed, if Candida non-albicans fungi were found, micafungin or amphotericin (8.0 %) was prescribed. The average number of ABT regimens in children with stage 3 NEC was 3.35±0.31. Thus, the use of a differentiated approach to NEC therapy, taking into account the data of a microbiological study, made it possible to reduce the mortality of patients to 39.3±6.57 %.


1. Namazova-Baranova L. S. Principles of staged nursing of premature babies. M.: «Pediatr», 2013. (In Russ.).
2. Obedin A. N., Kachanov A. V., Annenkov M. V., Tovkan E. A., Kiriyenko O. S. Necrotizing enterocolitis in newborns. Do we all do to save their patients? Meditsinskii Vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2015;10(2):140-143. https://doi.org/10.14300/mnnc.2015.10032
4. Abolina T. B., Tsap N. A., Chudakov V. B. Surgical results of treatment of necrotizing enterocolitis in premature infants with extremely low body weight. Rossysky vestnik detskoy khirurgii, anesteziologii i reanimatologii. – Russian Bulletin of Pediatric Surgery, Anesthesiology and Resuscitation. 2018;8:1. (In Russ.).
5. Minaev S. V., Obedin A. N., Kachanov A. V., Annenkov M. V., Tovkan E. A. Fast track in the treatment of newborns with necrotizing enterocolites. Medical News of North Caucasus. 2016;11(2):152-154. https://doi.org/10.14300/mnnc.2016.11023
6. Gephart Sh., Newnam K., Wyles Ch., Bethel C., Porter C. [et al.]. Development of the NEC-Zero Toolkit: Supporting Reliable Implementation of Necrotizing Enterocolitis Pre vention and Recognition. Neonatal Network. 2020;39:6-15. https://doi.org/10.1891/0730-0832.39.1.6
7. Shahbaz S., Maurice A., Sim M.-Sh., Rubin Z., Garg M. Effect of Contact Precautions on Staphylococcus aureus and Clinical Outcomes of Colonized Patients in the Neonatal Intensive Care Unit. Pediatr. Infect. Dis. J. 2020;39(11):1045-1049. https://doi.org/10.1097/INF.0000000000002795
8. Dobler P. T., Procianov R. S., Mai V., Silveira R. C., Corso A. L. [et al.]. Low Microbial Diversity and Abnormal Microbial Succession Is Associated with Necrotizing Enterocolitis in Preterm Infants. Front. Microbiol. 2017;8:2243. https://doi.org/10.3389/fmicb.2017.02243
9. Terrin G., Scipione A., De Curtis M. Update in Pathogenesis and Prospective in Treatment of Necrotizing Enterocolitis. BioMed Research International. 2014;543765. https://doi.org/10.1155/2014/543765
10. Dorofeeva E. I., Podurovskaya Yu. L., Burov A. A., Ryumina I. I., Narogan M. V. [et al.]. Diagnosis and conservative treatment of neonates with necrotizing enterocolitis. Clinical guidelines. 2014. (In Russ.).
11. Li X., Li X., Shang Q., Gao Z., Hao F. [et al.]. Fecal microbiota transplantation (FMT) could reverse the severity of experimental necrotizing enterocolitis (NEC) via oxidative stress modulation. Free Radical Biology & Medicine. 2017;108:32-43. https://doi.org/10.1016/j.freeradbiomed.2017.03.011
12. Zani A., Eaton S., Puri P., Rintala R. International survey on the management of necrotizing enterocolitis. Eur. J. Ped. Surg. 2015;25(1):27-33. https://doi.org/10.1055/s-0034-1387942
13. Kirgizov I. V., Minaev S. V., Shishkin I., Aprosimova S., Ukhina L. Surgical treatment of idiopathic megarectum in constipated children. J. Pediatric Surgery. 2019;54(7):1379-1383. https://doi.org/10.1016/j.jpedsurg.2018.10.103
14. Axelrov M. A., Ivanov V. V., Axelrov A. M., Sergienko T. V., Suprunets S. N. [et al.]. Stage treatment of complicated forms of progressive necrotizing enterocolitis in newborns. Meditsinskaya nauka i obrazovaniye Urala. – Medical science and education of the Urals. 2010;4(64):101-104. (In Russ.).
15. Minaev S. V., Isaeva A. V., Tovkan E. A., Gudiev Ch. G., Timofeev S. I. [et al.]. The prognostic value of bactericidal/permeability-increasing protein in infants with congenital pathology of the gastrointestinal tract. Medical News of North Caucasus. 2014;9(2):116-119. https://doi.org/10.14300/mnnc.2014.09032
16. Gordon P., Swanson J., Clark R., Spitzer A. The complete blood cell count in a refined cohort of preterm NEC: the importance of gestational age and day of diagnosis when using the CBC to estimate mortality. Journal of Perinatology. 2016;36:121-125. https://doi.org/10.1038/jp.2015.162
17. Tarakanov V. A., Minaev S. V., Kolesnikov E. G., Korotkov K. G., Abushkevich V. G. [et al.]. Topical diagnosis of the boundaries of necrotic segment of the small intestine in the high frequency electromagnetic fields. Meditsinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2019;14(2):308-311. (In Russ.). https://doi.org/10.14300/mnnc.2019.14074
18. Pell L., Loutet M., Roth D., Sherman Ph. Arguments against routine administration of probiotics for NEC prevention. Curr. Opin. Pediatr. 2019;31:195-201. https://doi.org/10.1097/MOP.0000000000000730
19. Livermore D. M. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare? Clin .Infect. Dis. 2002;34:634-640. https://doi.org/10.1086/338782
20. Geng Q., Wang Y., Li L., Guo Ch. Early postoperative outcomes of surgery for intestinal perforation in NEC based on intestinal location of disease. Medicine. 2018;97:e12234. https://doi.org/10.1097/MD.0000000000012234
21. Brooke J. S. Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen. Clin. Microbiol. Rev. 2012;25(1):2-41. https://doi.org/10.1128/CMR.00019-11
22. Podkamenev V. V., Grigoriev E. G. Necrotizing enterocolitis in newborns. M., 2010. (In Russ.).

Keywords: infants, necrotizing enterocolitis, microbiological research, antibacterial therapy

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy