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ISSN 2073-8137
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Age plastici ty of the neurons nitrergic subpopulations in the olfactory bulbs of rat

[Original research] [Experimental medicine]
Vyacheslav Varentsov; Tatiana Rumyantseva; Kirill Pshenisnov; Tamara Myasishcheva; Dmitry Pozhilov;

In immunohistochemical studies, n-NOS-positivity is detected in the bodies and processes of neurons. In the rat’s olfactory bulb, there are three subpopulations of n-NOS-positive neurons with different enzyme activity levels and different dynamics of age transformations. The heterogeneous enzyme activity is due to the different functions of neurons. That must be taken into account when interpreting the results of the experimental studies.

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References:
1.Obukhov D. K., Pushchina Ye. V., Varaksin A. A. Gazoobraznye mediatory v TsNS pozvonochnykh zhivotnykh. Uspekhi sovremennogo estestvoznaniya. – Advance of modern
science. 2011;(12):49-51. (In Russ.).
2.Varentsov V. E., Rumyantseva T. А. Vozrastnye osobennosti ehkspressii dablkortina v strukturakh obonyatel’nykh lukovits krysy. Zhurnal anatomii i gistopatologii. – Journal of Anatomy and Histopathology. 2017;(6):19-24. (In Russ.). https://doi.org/10.18499/2225-7357-2017-6-3-19-24
3.Odyvanova L. R., Sosunov A. A., Gatchev Ya., Cervos Navarro Dzh. Okis azota v nervnoj sisteme. Uspekhi sovremennoj biologii. – Advance of modern biology. 1997;117:374-389. (In Russ.).
4. Sun H., Tao J., Zhao Q., Xu G., Zhang Y. Multiple roles of nitric oxide in root development and nitrogen uptake. Plant Signaling & Behavior. 2017;12(1):e1274480. https://doi.org/10.1080/15592324.2016.1274480
5. Matarredona E. R., Murillo-Carretero M., Moreno-López B., Estrada C. Role of nitric oxide in subventricular zone neurogenesis. Brain Research Reviews. 2005;49:355-366. https://doi.org/10.1016/j.brainresrev.2005.01.001
6. Benton J. L., Sandeman D. C., Beltz B. S. Nitric oxide in the crustacean brain: regulation of neurogenesis and morphogenesis in the developing olfactory pathway. Developmental Dynamics. 2007;236:3047-3060. https://doi.org/10.1002/dvdy.21340
7. Knowles R. G., Moncada S. Nitric oxide synthases in mammals. The Journal of Biochemistry. 1994;298:249-258.
8. Aniol V. A., Stepanichev M. Yu. Oksid azota i gammaaminomaslyanaya kislota kak regulyatory nejrogeneza v mozge vzroslyh mlekopitayushchih pri modelirovanii sudorozhnoj aktivnosti. Nejrohimiya. – Neurochemistry. 2007;(1):265-274. (In Russ.).
9. Bredt D. S., Hwang P. M., Snyder S. H. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature. 1990;347:768-770.
10. Kiss J. P., Vizi E. S. Nitric oxide: a novel link between synaptic and non-synaptic transmission. Trends in Neurosciences. 2001;24:211-215.

Keywords: olfactory bulb, neurogenesis, n-NO-synthase, ontogenesis


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