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https://doi.org/10.14300/mnnc.2022.17107

Epigenetic mechanisms in epilepsy. Paradigm shift in seizure prevention and treatment

[Reviews]
Galina Aleksandrovna Afanaseva; Anna Vyacheslavovna Fisun; Evgeny Shchetinin;

The main epigenetic approaches for understanding the pathogenesis of epileptic seizures are considered, the leading components of the formation of convulsive activity in the neurons of the cerebral cortex are given, taking into account changes in DNA methylation systems, modification of histones and non-coding RNAs. The possibility of pathogenetically justified optimization of the regulation of epileptogenesis by interfering with the epigenetic control of neuronal function is discussed.

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Keywords: epilepsy, neurons, epigenetics, DNA methylation, histone modification