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https://doi.org/10.14300/mnnc.2018.13056

Effect of combined oral contraceptives conaining drospirenone + ethinylestradiol on the mammary gland condition in women of reproductive age

[Obstetrios and gynecology]
Vladislava Novikova; Vadim Khorolsky; Natalia Strelnikova; Galina Makarenko; Susanna Gasparyan; Lyudmila Tkachenko; Marina Selikhova; Margarita Andreeva;

Drospirenone, as a part of combined oral contraceptives, has an antiproliferative effect on hyperplastic processes in the organs of the female reproductive system. Individual selection of COCs taking into account the dose and properties of the gestagenic and estrogenic components allows, with contraceptive and non-contraceptive purposes, to prescribe it to women of reproductive age. Intake of COC containing drospirenone + ethinyl estradiol is not associated with impaired drug tolerance due to complaints of soreness and breast engorgement in the first 3 months. 6 months of COCs containing drospirenone + ethinyl estradiol are significantly associated with a decrease in the frequency of clinical and US-signs of dyshormonal dysplasia of the breast.

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Keywords: fibrocystic mastopathy, combined oral contraceptives, drospirenone