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Diverticular disease of the collon: clinic -instrumental and immunomorphological parallels
[Internal diseases]
Andrey Svistunov; Mikhail Osadchuk; Natalia Kireeva; Alexandra Zolotovitskaya; Alisa Lasareva; Dariya Shorina; Nikolai Antonenko; Maksim Osadchuk;
Diverticular colon disease, taking into account the increase in the proportion of older people in the total population of the planet, is one of the most important problems of modern health care, due to the need for constant monitoring of patients due to the possible development of complications such as diverticulitis, perforation, bleeding and malignancy. From these positions, it becomes relevant to develop early prognostic criteria for the severity of the diverticular colon disease based on the study of the main indicators of proliferation, such as Kisspeptin (KiSS1), p53, chromogranin-a (CgA).
References:
1. Everhart J., Ruhl C. Burden of Digestive Diseases in the United States Part II: Lower Gastrointestinal Diseases. Gastroenterology. 2009;136(3):741-754. https://doi.org/10.1053/j.gastro.2009.01.015
2. Peery A. F., Sandler R. S., Ahnen D. J., Galanko J. A., Holm A. N. [et al.]. Constipation and a low-fiber diet are not associated with diverticulosis. Clinical Gastroenterology and Hepatology. 2013;11(12):1622-1627. https://doi.org/10.1016/j.cgh.2013.06.033
3. Lee J.-H., Miele M. E., Hicks D. J., Phillips K. K., Trent J. M., Weissman B. E., Welch D. R. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene. J. Nat. Cancer Ins. 1996;88(23):1731-1737. https://doi.org/10.1093/jnci/88.23.1731
4. Castellano J. M., Gaytan M., Roa J., Vigo E., Navarro V. M. [et al.]. Expression of KiSS-1 in rat ovary: putative local regulator of ovulation? Endocrinology. 2006;147(10):4852-4862. https://doi.org/10.1210/en.2006-0117
5. Mead E., Maguire J., Kuc R., Davenport A. Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system. Br. J. Pharmacol. 2009;151(8):1143-1153. https://doi.org/10.1038/sj.bjp.0707295
6. Mead E., Maguire J., Kuc R., Davenport A. Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels. Endocrinology. 2007;148(1):140–147. https://doi.org/10.1210/en.2006-0818
7. Kolesnik A. P. Prognosticheskoye znacheniye ekspressii p53 u bolnykh s rannimi stadiyami nemelkokletochnogo raka legkogo. Onkologiya. – Oncology. 2013;15(1):20- 23. (In Russ.).
8. Kleist B., Poetsch M. Neuroendocrine differentiation: The mysterious fellow of colorectal cancer. World J. Gastroenterol. 2015;21(41):11740-11747. https://doi.org/10.3748/wjg.v21.i41.11740
9. Liu Y., He J., Xu J., Li J., Jiao Y. [et al.]. Neuroendocrine differentiation is predictive of poor survival in patients with stage II colorectal cancer. Oncol. Lett. 2017;13(4): 2230-2236. https://doi.org/10.3892/ol.2017.5681
10. Cai L., Kaneko S., Morita E. Changes in salivary chromogranin A levels in adults with atopic dermatitis are correlated with changes in their condition. J. Dermatol. 2018;45(5): 554-559. https://doi.org/10.1111/1346-8138.14277
11. Kalkan C., Karakaya F., Soykan I. Factors associated with elevated serum chromogranin A levels in patients with autoimmune gastritis. The Turkish J. Gastroenterology. 2016;27(6): 515-520. https://doi.org/10.5152/tjg.2016.16486
12. Linninge C., Roth B., Erlanson-Albertsson C., Molin G., Toth E., Ohlsson B. Abundance of Enterobacteriaceae in the colon mucosa in diverticular disease. World J. Gastrointest. Pathophysiol. 2018;9(1):18-27. https://doi.org/10.4291/wjgp.v9.i1.18
13. Huma T., Wang Z., Rizak J., Ahmad F., Shahab M., Ma Y., Yang S., Hu X. Kisspeptin-10 modulates the proliferation and differentiation of the rhesus monkey derived stem cell line: R366.4. Sci. World J. 2013;2013:1-7. https://doi.org/10.1155/2013/135470
14. Popp C., Nichita L., Voiosu T., Bastian A., Cioplea M. [et al.]. Expression Profile of p53 and p21 in Large Bowel Mucosa as Biomarkers of Inflammatory-Related Carcinogenesis in Ulcerative Colitis. Dis. Markers. 2016;2016: 1-7. https://doi.org/10.1155/2016/3625279
15. Kobayashi K., Tomita H., Shimizu M., Tanaka T., Suzui N., Miyazaki T., Hara A. p53 Expression as a Diagnostic Biomarker in Ulcerative Colitis-Associated Cancer. Int. J. Mol. Sci. 2017;18(6):1284. https://doi.org/10.3390/ijms18061284
16. El-Salhy М., Gilja О. Abnormalities in ileal stem, neurogenin 3, and enteroendocrine cells in patients with irritable bowel syndrome. BMC Gastroenterol. 2017;17(1):90. https://doi.org/10.1186/s12876-017-0643-4
17. Mujagic Z., Jonkers D. M. A. E., Ludidi S., Keszthelyi D., Hesselink M. A. [et al.]. Biomarkers for visceral hypersensitivity in patients with irritable bowel syndrome. Neurogastroenterology & Motility. 2017;29(12):e13137. https://doi.org/10.1111/nmo.13137
18. Eissa N., Hussein H., Kermarrec L., Ali A. Y., Marshall A. [et al.]. Chromogranin-A Regulates Macrophage Function and the Apoptotic Pathway in Murine DSS colitis. J. Molec. Med. 2017;96(2):183-198. https://doi.org/10.1007/s00109-017-1613-6
Keywords: diverticular colon disease, кisspeptin, р53, chromogranin-a
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy