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https://doi.org/10.14300/mnnc.2019.14030

Peculiarities of alloxan -induced diabetes mellitus in experimental rats

[Original research] [Experimental medicine]
Anna Khodzhayan; Margarita Gevandova; Evgenia Markarova; Elena Diskaeva; Fatima Askhatovna Bidzhieva; Karine Elbekyan;

In this article was carried analysis of specificity and expressiveness of reproduction of an experimental model of a diabetes of the first phylum on rats-males of a line of Vistar. With the introduction of alloxan in a dose of 150 mg/kg revealed diabetic-uremic syndrome. The ratio of animals with a syndrome of high and low uremic sensitivity to the drug was 31 and 24 %, respectively. In these groups, lipid and carbohydrate metabolism, pro- and antioxidant status, the level of the hormone corticosterone, as well as the activity of AST and ALT were studied. The results we obtained allow us to study in more detail the dynamics of the development of the pathological state and the study of the methods of its modulation with various compounds.

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Keywords: diabetes, alloxan, alloxan sensitivity, endocrine and metabolic disorders