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https://doi.org/10.14300/mnnc.2019.14027

Effect of chronic neurogenic pain on receptor status of the skin and growing skin tumor in female mice with transplantable b16/f10 melanoma

[Original research] [Experimental medicine]
Elena Frantsiyants; Valeriya Bandovkina; Irina Kaplieva; Yulia Pogorelova; Lydia Trepitaki; Inga Movlievna Kotieva;

The changes in the receptor status of the skin and growing skin tumor under the influence of chronic neurogenic pain in female С57ВL/6 mice with transplantable B16/F10 melanoma were studied. Steroid hormone receptors were determined by ELISA in samples of the skin, tumor and perifocal tissues. Chronic pain affected the receptor status of the skin, upregulating estrogen receptors and downregulating androgen receptors. Mice of the main group showed an early tumor onset, active metastasis and poor survival, compared to the comparison group. The tumor onset in animals of both groups caused similar changes in the skin levels of estrogen receptors and opposite changes in androgen and progesterone receptors. Melanoma samples were characterized by elevated levels of all the studied steroid receptors, similar to the perifocal tissues in animals of the main group. Hormonal imbalance caused by neurogenic pain and changes in the content of steroid hormone receptors in the skin contributes to an earlier onset of transplantable melanoma and enhances its biological aggressiveness shown through active metastasis.

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Keywords: estrogen receptors, androgen receptors, progesterone receptors, В16/F10 melanoma, chronic neurogenic pain