logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Effect of chronic neurogenic pain on receptor status of the skin and growing skin tumor in female mice with transplantable b16/f10 melanoma

[Original research] [Experimental medicine]
Elena Frantsiyants; Valeriya Bandovkina; Irina Kaplieva; Yulia Pogorelova; Lydia Trepitaki; Inga Movlievna Kotieva;

The changes in the receptor status of the skin and growing skin tumor under the influence of chronic neurogenic pain in female С57ВL/6 mice with transplantable B16/F10 melanoma were studied. Steroid hormone receptors were determined by ELISA in samples of the skin, tumor and perifocal tissues. Chronic pain affected the receptor status of the skin, upregulating estrogen receptors and downregulating androgen receptors. Mice of the main group showed an early tumor onset, active metastasis and poor survival, compared to the comparison group. The tumor onset in animals of both groups caused similar changes in the skin levels of estrogen receptors and opposite changes in androgen and progesterone receptors. Melanoma samples were characterized by elevated levels of all the studied steroid receptors, similar to the perifocal tissues in animals of the main group. Hormonal imbalance caused by neurogenic pain and changes in the content of steroid hormone receptors in the skin contributes to an earlier onset of transplantable melanoma and enhances its biological aggressiveness shown through active metastasis.

Download

References:
1. Machelska H., Chelik M. O. Recent advances in understanding neuropathic pain: glia, sex differences, and epigenetics. F1000Research. 2016;5:2743. https://doi.org/10.12688/f1000research.9621.1
2. Abuzarova G. R., Daryalova S. L., Sarmanayeva R. R. Neyropaticheskaya
bol v onkologii. Onkologiya. Zhurnal im. P. A. Gertsena. Oncology. Journal them. P. A. Herzen. 2013;1(4):86-90. (In Russ.)
3. Deius J. R., Dvorakova L. S., Vetter I. Methods used to assess the behavior of pain in rodents. Frontiers in Molecular Neuroscience. 2017;10:284. https://doi.org/10.3389/fnmol.2017.00284
4. Henry N. L., Conlon A., Kidwell K. M., Griffith K., Smerage J. B. [et al.]. The effect of estrogens on the depletion of pain sensitivity in aromatase inhibitor-treated women with early stage breast cancer. Journal of Pain. 2014;15(5):468-475. https://doi.org/10.1016/j.jpain.2014.01.487
5. Maurer A. J., Lissounov A., Knezhevich I., Candido K. D., Knezhevich N. N. Pain and sex hormones: an overview of modern understanding. Pain Management. 2016;6(3):285-296. https://doi.org/10.2217/pmt-2015-0002
6. Bartley E. J., Palit S., Kuhn B. L., Kerr K. L., Terry E. L. [et al.]. Natural variation in testosterone is associated with hypoalgesia in healthy women. The Clinical Journal of Pain. 2015;31(8):730-739. https://doi.org/10.1097/AJP.0000000000000153
7. Mitchell D. L., Fernandez A. A., Garcia R., Paniker L., Lin K. [et al.]. Acute exposure to ultraviolet-B radiation modulates sex steroid hormones and receptor expression in the skin and may contribute to the sex bias of melanoma in a fish model. Pigment Cell Melanoma Research.2014;27:408-417. https://doi.org/10.11/pcmr.12213
8. Liu F., Bessonova L., Taylor T. H., Ziogas A., Meyskens F. L. [et al.]. A unique gender difference in early onset melanoma implies that in addition to ultraviolet light exposure other causative factors are important. Pigment Cell Melanoma Research. 2013;26:128-135. https://doi.org/10.11/pcmr.12035
9. Roh M. R., Eliades P., Gupta S., Grant-Kels J. M., Tsao H. Cutaneous melanoma in women. International Journal of Women’s Dermatology. 2017;1(1):21-25. https://doi.org/10.1016/j.ijwd.2017.02.003
10. Hall G., Phillips T. J. Estrogen and skin: the effects of estrogen, menopause, and hormone replacement therapy on the skin. Journal of the American Acadademy of Dermatology. 2005;53(4):569-571. https://doi.org/10.1016/j.jaad.2004.08.039
11. Rong C., Meinert E. F., Hess J. Estrogen Receptor Signaling in Radiotherapy: From Molecular Mechanisms to Clinical Studies. International Journal of Molecular Sciences. 2018;19(3):713. https://doi.org/10.3390/ijms19030713
Bandovkina V. A., Frantsiyants E. M., Kaplieva I. V., Kozlova M. B., Trepitaki L. K. [et al.]. Osobennosti regulyatsii gormonalnogo balansa kozhi u samok myshey
v dinamike rosta perevivnoy melanomy B16/F10. Translyatsionnaya meditsina. – Translational medicine. 2017;4(3):45-53. (In Russ.). ttps://doi.org/10.18705/2311-4495-2017-4-3-45-53
13. Kotieva I. M., Kit O. I., Frantsiyants E. M., Bandovkina V. A., Kaplieva I. V. [et al.]. Vliyaniye khronicheskoy boli na uroven polovykh gormonov, prolaktina i gonadotropnykh gormonov v syvorotke krovi i patologicheski izmenennoy kozhe u samok myshey v dinamike rosta zlokachestvennoy melanomy. Izvestiya vysshikh uchebnykh zavedeniy. Severo-Kavkazskiy region. Seriya: Estestvennyye
nauki. Proceedings of Higher Educational Institutions. North Caucasus region. Series: Natural Sciences. 2018;198(2):106-116. (In Russ.). https://doi.org/10/23683/0321-3005-2018-2-121-132
14. Frantsiyants E. M., Bandovkina V. A., Komarova E. F., Pozdnyakova V. V., Pogorelova Yu. A. Gormonalnyy profil melanomy i okruzhayushchikh
yeye tkaney. Molekulyarnaya meditsina. Molecular medicine. 2014;(6):48-51. (In Russ.).

Keywords: estrogen receptors, androgen receptors, progesterone receptors, В16/F10 melanoma, chronic neurogenic pain


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy