logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Research of mechanisms of neurodegenerative processes in experimental metabolic syndrome

[Original research] [Experimental medicine]
Alexander Sergeevich Kucherenko; Vitalina Igorevna Petrenko; Anatoly Vladimirovich Kubyshkin; Irina Ivanovna Fomochkina; Vladislav Vladislavovich Tkach; Leya Evgenievna Sorokina; Yuri Alekseevich Ogay; Yulianna Ivanovna Shramko;

On 82 white Wistar rats the data on the relation of inflammatory changes in blood and brain tissue of rats with the level of expression of brain neurotrophic factor (BDNF), the distribution of neuronal NO-synthase (nNOS) in the brain and the degree of cognitive disorders in rats with MS were obtained. Morphological verification of the development of neurodegenerative processes in the form of reducing the thickness of the temporo-parietal cortex and the density of arrangement of the cells of the dorsal hippocampus in the brain of rats exposed to MS was received. The complex substantiation of pathogenetic approach to effective neuroprotection and prevention of neurodegenerative changes in MS in the form of polyphenols, in particular resveratrol, as well as azilsartane has been carried out.

Download

References:
1. World Health Organization. Global Report on Diabetes. Geneva, Switzerland, World Health
Organization; 2016.
2. Balkau B., Charles M. A. Comment on the provisional report from the WHO consultation. European group for the study of insulin resistance (EGIR). Diabetic medicine: a journal of the British Diabetic Association. 1999;16:442-443.
3. Wilson P. W. F., D’Agostino R. B., Parise H., Sullivan L., Meigs J. B. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation. 2005;112:3066-3072. https://doi.org/10.1161/CIRCULATIONAHA.105.539528
4. Mazza A., Pessina A. C., Zamboni S., Casiglia E. Prognostic role of metabolic syndrome in the elderly is not greater than the sum of its components. Aging Health.
2010;6(2):217-228. https://doi.org/10.2217/ahe.10.9
5. Crichton G. E., Elias M. F., Buckley J. D., Murphy K. J., Bryan J. [et al.]. Metabolic syndrome, cognitive performance, and dementia. Journal of Alzheimers Disease. 2012;30(Suppl 2):S77-87. https://doi.org/10.3233/JAD-2011-111022
6. Siervo M., Harrison S. L., Jagger C., Robinson L., Stephan B. C. Metabolic syndrome and longitudinal changes in cognitive function: a systematic review and metaanalysis. Journal of Alzheimers Disease. 2014;41(1):151-161. https://doi.org/10.3233/JAD-132279
7. Craft S., Watson G. S. Insulin and neurodegenerative disease: shared and specific mechanisms. The Lancet Neurology. 2004;3:169-178. https://doi.org/10.1016/S1474-4422(04)00681-7
8. Panza F., Frisardi V., Capurso C., Imbimbo B. P., Vendemiale G. [et al.]. Metabolic syndrome and cognitive impairment: Current epidemiology and possible underlying mechanisms. Journal of Alzheimers Disease. 2010;21:691-724. https://doi.org/10.3233/JAD-2010-091669
9. Ishimoto T., Lanaspa M. A., MyPhuong T. L., Garcia G. E. Opposing effects of fructokinase C and A isoforms on fructose-induced metabolic syndrome in mice. Proceedings of the National Academy of Sciences USA. 2012;109(11):4320-4325. https://doi.org/10.1073/pnas.1119908109
10. Krikun G., Trezza J., Shaw J., Rahman M., Guller S. Lipopolysaccharide appears to activate human endometrial endothelial cells through TLR-4-dependent and TLR-4-independent mechanisms. American Journal of Reproductive Immunology. 2012;68:233-237. https://doi.org/10.11/j.1600-0897.2012.01164.x
11. Motamedi S., Karimi I., Jafari F. The interrelationship of metabolic syndrome and neurodegenerative diseases with focus on brain-derived neurotrophic factor (BDNF): Kill two birds with one stone. Metabolic Brain Disease. 2017;32:651. https://doi.org/10.1007/s11011-017-9997-0
12. Frisardi V., Imbimbo B. P. Metabolic-cognitive syndrome: Metabolic approach for the management of Alzheimer’s disease risk. Journal of Alzheimers Disease.
2012;30(S1):S1-S4. https://doi.org/10.1016/j.arr.2010.04.007
13. Bredt D. S., Glatt C., Hwang P. M. Nitrix oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase. Neuron. 1991;7:615-620. https://doi.org/10.1016/0896-6273(91)90374-9
14. Zahedi As. S., Ghasemi A., Azizi F. Serum nitric oxide metabolites in subjects with metabolic syndrome. Clinical Biochemistry. 2008;41:1342-1347. https://doi.org/10.1016/j.clinbiochem.2008.08.076
15. Vincent S. R. Nitric oxide: a radical neurotransmitter in the central nervous system. Progress in Neurobiology. 1994;42:129-131. https://doi.org/10.1016/0301-0082(94)90023-X
16. Park J. H., Kho M. C., Kim H. Y., Ahn Y. M., Lee Y. J. Blackcurrant Suppresses Metabolic Syndrome Induced by High-Fructose Diet in Rats. Evidence-Based Complementary and Alternative Medicine. 2015:385976. https://doi.org/10.1155/2015/385976

Keywords: neurodegeneration, metabolic syndrome, BDNF, nNOS, cognitive impairment, hippocampus, polyphenols, resveratrol, azilsartan


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy