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EBSCO

Research of mechanisms of neurodegenerative processes in experimental metabolic syndrome

[Original research] [Experimental medicine]
Alexander Sergeevich Kucherenko; Vitalina Igorevna Petrenko; Anatoly Vladimirovich Kubyshkin; Irina Ivanovna Fomochkina; Vladislav Vladislavovich Tkach; Leya Evgenievna Sorokina; Yuri Alekseevich Ogay; Yulianna Ivanovna Shramko;

On 82 white Wistar rats the data on the relation of inflammatory changes in blood and brain tissue of rats with the level of expression of brain neurotrophic factor (BDNF), the distribution of neuronal NO-synthase (nNOS) in the brain and the degree of cognitive disorders in rats with MS were obtained. Morphological verification of the development of neurodegenerative processes in the form of reducing the thickness of the temporo-parietal cortex and the density of arrangement of the cells of the dorsal hippocampus in the brain of rats exposed to MS was received. The complex substantiation of pathogenetic approach to effective neuroprotection and prevention of neurodegenerative changes in MS in the form of polyphenols, in particular resveratrol, as well as azilsartane has been carried out.

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Keywords: neurodegeneration, metabolic syndrome, BDNF, nNOS, cognitive impairment, hippocampus, polyphenols, resveratrol, azilsartan