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https://doi.org/10.14300/mnnc.2019.14012

Effects of monothera py by fabomotisol at cobalt intoxication in experiment

[Original research] [Experimental medicine]
Sergey Dzugkoev; Fira Dzugkoeva; Mikhail Otiev; Olga Marghiev; Irina Mozhayeva;

In studies in experimental rats with cobalt intoxication, the antioxidant effect of fabomotisole was established by reducing the concentration of malonic dialdehyde (MDA) in erythrocytes, homogenates of renal, hepatic and myocardial tissues. Against the background of monotherapy with fabomotisole, imbalance in the system of lipid peroxidation – an antioxidant system with a simultaneous increase in the concentration of total metabolites of nitric oxide – was reduced. Since the content of nitric oxide depends on the availability of the substrate-L-arginine and eNOS expression, we investigated the state of cholesterol metabolism and found an increased content of atherogenic β-lipoproteins and a decrease in the highdensity lipoprotein content. Disrupted cholesterol metabolism causes a predaterogenic change in the vascular system and promotes the development of endothelial dysfunction, which is a risk factor for damage to internal organs. The data showed that along with the antioxidant effect, fabomotisole stimulates the activity of Na,K-ATPase in homogenates of internal organs and reduces the content of enzyme-specific enzymes in the serum.

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Keywords: cobalt chloride, lipid peroxidation, nitric oxide, fabomotisol, endothelial dysfunction, cholesterol exchange