logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Antiinflammatory effects of silt-sulphide peloids on the experimental model «adjuvant arthritis » in rats

[Original research] [Experimental medicine]
Kermen Badmaeva; Nadezhda Abushinova; Davvid Teplyi;

On the experimental model of rheumatoid arthritis caused in albino rats by the subplantar administration of incomplete Freund’s adjuvant, proved protective and therapeutic anti-inflammatory effects of silt-sulphide peloids of the Lake «Large Yashaltinskoe». Analysis of the primary reaction to the administration of adjuvant and histological control of the joint revealed a significant decrease in the degree of hyperemia and edema of the limb, as well as a significant stabilization of the connective tissue in the periosteum in the experimental animals receiving peloidotherapy, in comparison with the animals of the control group.

Download

References:
1. Kurbanov V. A. Vlijanie preformirovannogo preparata iz zheltoj gliny v sravnenii s lechebno jgrjaz’ju ozera «Tambukan» na techenie ad’juvantnogo artrita. Kurortnaja medicina. – SPA Medicine. 2014;(4):31-36. (In Russ.)
2. Bogolyubov V. M., Sidorov V. D. Fizioterapija v reabilitacii bol’nyh revmatoidnym artritom. Fizioterapija, balneologija i reabilitacija. – Physiotherapy, balneology and rehabilitation. 2012;(2):3-11. (In Russ.)
3. Barnes D. Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvantinduced arthritis model. Journal of Clinical Investigation. 1998;101(12):2910–2919. https://doi.org/10.1172/JCI2172
4. Cozzi F. Anti-inflammatory effect of mud-bath applications on adjuvant arthritis in rats. Clinical and Experimental Rheumatology. 2004;22(6):763-766.
5. Gálvez I., Torres-Piles S., Ortega-Rincón E. Balneotherapy, Immune System, and Stress Response: A Hormetic Strategy? International journal of molecular sciences. 2018;19(6):1687. https://doi.org/10.3390/ijms19061687
6. Sheveleva N. I., Minbaeva L. S. Sovremennyj vzgljad na problem reabilitacii patologii sustavov. Klinicheskaja medicina Kazahstana. – Clinical Medicine of Kazakhstan. 2016;40(2):117-120. (In Russ.)
7. Karagülle M. Effect of spa therapy with saline balneotherapy on oxidant/antioxidant status in patients with rheumatoid arthritis: a single-blind randomized controlled trial. International Journal of Biometeorology. 2017;61(1):169- 180. https://doi.org/10.1007/s00484-016-1201-4
8. Wells G. Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythrocyte sedimentation rate. Annals of the Rheumatic Diseases. 2009:68(6):954-960. http://doi.org/10.1136/ard.2007.084459
9. Efimenko N. V., Abramcova A. V., Kajsinova A. S. Izuchenie immunologicheskih effektov novogo balneologicheskogo sredstva glinofir pri adjuvantnom artrite. Voprosy kurortologii, fizioterapii i lechebnoj fizicheskoj kultury. – Questions of balneology, physiotherapy and medical physical culture. 2016;93(4):56-59. (In Russ.). http://doi.org/10.17116/kurort2016456-59
10. Badalov N. G. Rol nemedikamentoznyh metodov v komplekse meroprijatij po profilaktike i lecheniju osteoporoza (obzor literatury). Sovremennaja revmatologija. – Modern rheumatology. 2016;10(3):62-68. (In Russ.) https://doi.org/10.14412/1996-7012-2016-3-62-68
11. Britschka Z. M. N. The efficacy of Brazilian black mud treatment in chronic experimental arthritis. Rheumatology International. 2007;28(1):39-45. https://doi.org/10.1007/s00296-007-0371-0
12. Chen H. Tibetan medicated-bath therapy may improve adjuvant arthritis in rat. Evidence-Based Complementary and Alternative Medicine. 2009;6(2):211-217. http://doi.org/10.1093/ecam/nem083
13. Spilioti E., Vargiami M., Letsiou S., Gardikis K., Sygouni V. [et al.]. Biological properties of mud extracts derived from various spa resorts. Environmental Geochemistry and Health. 2017;39(4):821-833. https://doi.org/10.1007/s10653-016-9852-y
14. Santos I., Cantista P., Vasconcelos C. Balneotherapy in rheumatoid arthritis – a systematic review. International Journal of Biometeorology. 2016;60(8):1287-1301. https://doi.org/10.1007/s00484-015-1108-5
15. McInnes I. B., Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nature Reviews Immunology. 2007;7(6):429-432. https://doi.org/10.1038/nri2094 16. Paleolog E. M. Angiogenesis in rheumatoid arthritis. Arthritis Research & Therapy.2002;4(3):81-84. https://doi.org/10.1186/ar575

Keywords: adjuvant arthritis, silt-sulphide peloids


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy