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ISSN 2073-8137

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Pathomorphological status of periodontal tissues during bisphosphona tetherapy (experimental research)

[Original research] [Experimental medicine]
Victoria Atrushkevich; Gennady Berchenko; Lyudmila Orekhova; Ekaterina Loboda;

A pathological morphological assessment of the periodontal tissues was carried out against the background of the administration of bisphosphonates to rats after preliminary modeling of metabolic disorders by ovariectomy. It has been established that ovaectomy promotes the development of osteonecrosis of the lower jaw of animals after administration of zoledronic acid. Two months after the administration of the drug, ovariectomized rats showed varying degrees of severity and signs of rarefaction of the alveolar bone with a decrease in the number of collagen fibers of the periodontal ligament and an increase in cellular infiltration with histiocytes and fibroblasts. The signs of coagulation necrosis with the subsequent formation of a pronounced chronic inflammatory process and partial lysis of the affected bone area were revealed. In control animals and rats without oophorectomy, the introduction of bisphosphonates did not cause such changes in the mandible bone. The development of osteonecrosis of the jaws against the background of the use of bisphosphonates may be accompanied by inflammatory processes and necrosis against the background of the already existing metabolic changes in periodontal tissues.


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Keywords: osteonecrosis of the jaws, bisphosphonates, periodontal tissues

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy