logo
Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
rus
русский
eng
english

Site search



Correspondence address
310 Mira Street, Stavropol, Russia, 355017

Tel
+7 8652 352524; +7 8652 353229.

Fax
+7 8652 352524.

E-mail
medvestnik@stgmu.ru

Effect of selective immunotherapy on recurrence rate of small pelvis adhesive process caused by external genital endometriosis

[Original research] [Obstetrios and gynecology]
Roman Pavlov; Ants Pydra; Victor Aksenenko;

In order to study the effect of selective immunotherapy on recurrence of pelvic adhesions after surgery for external genital endometriosis we evaluated subpopulations and cytokines production of immunocompetent cells in peripheral blood of 41 patients with external genital endometriosis with pelvic adhesive process before and after completion of «Roncoleukin» therapy, and the frequency of recurrence of adhesions in 50 patients with external genital endometriosis after surgical treatment. According to the results obtained in patients with pelvic adhesive process treated by «Roncoleukin» we observed an increase in the number of CD4, CD16, CD25-lymphocytes, as well as increase in the production of blood mononuclear cells IL1β, IL2, and IFNγ. The use of «Roncoleukin» in the postoperative period reduced the relapse rate in patients with adhesions and external endometriosis by 2.5 times. Thus, the proposed scheme for the prevention of recurrence of adhesions in patients with pelvic endometriosis can reduce the frequency of their occurrence more than 2 times.

Download

References:
1. Adamyan L. V. Akusherstvo i ginekologiya. 2006;11–17.
2. Antsupova B. C. Effektivnost lokalnoy immunokorrektsii v kompleksnom lechenii spayechnykh protsessov organov malogo taza. 2006;147.
3. Golovkina N. V. Diagnostika i prognozirovaniye spayechnogo protsessa u patsiyentok s chrevosecheniyami v anamneze pered laparoskopiyey. 2005;30
4. Makhmudova G. M., Popov A. V. Rossysky vestnik akusherctva-ginekologii. 2004;2:27–30.
5. Savitsky G. A., Gorbushin S. M. Elbi. 2002;170.
6. Korsak V. S. , Vasilyeva O. Ye., Isakova E. V. Problemy reproduktsii. 2006;3:41–46.
7. Cheong Y. C., Laird S. M., Shelton J. B. Human Reproductive. 2002;17:1039–1045.
8. Pizzo A., Salmeri F. M., Ardita F. V. Gynecol Obstet Invest. 2002(2):82–87.
9. Wu M. Y. , Ho H. N. Am J Reprod Immunol. 2003;49(5):285–296.

Keywords: endometriosis, adhesions, immunology


Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy