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The aim of this study was to investigate the influence of bactericidal/permeability-increasing protein (BPI) on the development of complications after abdominal surgery in infants
We investigated the intestinal hormone levels in the blood before and after surgery (1, 3, 7 and 14 postoperative days) in 24 infants with congenital intestinal obstruction anomaly and atresia. The children were divided into group 1 (N=10), which included newborns with inflammatory complications after the surgery, and group 2 (N=14), which included newborns without inflammatory complications. Twenty infants without operative treatment formed the control group. The level of BPI was determined by ELISA.
The level of BPI before surgery in group 2 was significantly higher than that in group 1 (10.5 ng/ml (3.35–19.05) and 3.33 ng/ml (2.74–4.51) p<0.05, respectively). In a group data comparison, BPI was significantly higher in group 1, even on the third day after surgery (2.915 ng/ml (1.37–55.5) and 15.75 ng/ml (3.32–50.5) p<0.05, respectively). The data showed values of BPI in the group of patients with inflammatory complications that were higher than those in the main and comparison groups from the third postoperative day.
The increased BPI in the blood on the first post- operative day in newborns was a good prognostic sign. An initial low-level BPI and the increased BPI in the blood on the third postoperative day in newborns was a poor prognostic sign and was evidence of development of inflammatory complications.
1. Grosfeld J. L., Othersen H. B. A tribute to Orvar Swenson on his 100th birthday. J. Pediatr. Surg. 2009;44(2):475. doi: 10.1016/j.jpedsurg.2009.01.004.
2. Warner B. W. Adaptation: paradigm for the gut and an academic career. J. Pediatr. Surg. 2013;48(1):20-26. doi: 10.1016/j.jpedsurg.2012.10.014.
3. Minaev S. V., Obozin V. S., Barnash G. M., Obedin A. N. The influence of enzymes on adhesive processes in the abdominal cavity. Eur. J. Pediatr. Surg. 2009;19(6):380- 383. doi: 10.1055/s-0029-1241847.
4. Minaev S. V., Tovkan E. A., Kachanov A. V., Isaeva A. V. An improvement of treatment newborns optimization of management of necrotizing enterocolitis in newborns. Medicinskii Vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2013;8(3):30-34. doi: 10.14300/ mnnc.2013.08007.
5. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 2002;415(6870):389-395.
6. Rowland K. J., Yao J., Wang L. et al. Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection. J. Pediatr. Surg. 2013;48(6):1330-1339. doi: 10.1016/j.jpedsurg.2013.03.031.
7. Schultz H., Weiss J. P. The bactericidal/permeability increasing protein (BPI) in infection and inflammatory disease. Clin. Chim. Acta. 2007;384(1-2):12-23.
8. Minaev S. V., Kirgizov I. V., Obedin A. N. et al. Monitoring of inflammatory complications development in the newborns with congenital pathology of the gastrointestinal tract. Medicinskii Vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2013;8(2):30-33.
9. Cahill R. A., Wang J. H., Redmond H. P. Enteric bacteria and their antigens may stimulate postoperative peritoneal adhesion formation. Surgery. 2007;141(3):403-410.
10. Giroir B. P., Scannon P. J., Levin M. Bactericidal/permeability-increasing protein – lessons learned from the phase III, randomized, clinical trial of rBPI21 for adjunc- tive treatment of children with severe meningococcemia. Crit. Care Med. 2001;29(7 Suppl):S130-135. Review.
11. Yamagata M., Rook S. L., Sassa Y. et al. Bactericidal/permeability-increasing protein’s signaling pathways and its retinal trophic and antiangiogenic effects. Faseb. J. 2006;20(12):2058-2067.
Keywords: astrointestinal tract, congenital anomaly, infants, bactericidal/permeability-in- creasing protein