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https://doi.org/10.14300/mnnc.2023.18067

Influence of melatonin on the processes of hemocoagulation, lipoperoxidation and disturbance of the urinary kidneys function in the chronic chromium compounds intoxication

[Original research] [Experimental medicine]
Vadim Brin; Elmira Gagloeva; Nikolay Valeryevich Sokolovsky;

An experiment on Wistar rats showed that intragastric administration of melatonin 5 mg/kg can help to prevent disorders in the hemostasis system and urinary kidneys function in the cases of toxic effect of potassium dichromate for two months. A correlation was found between changes in parameters in the hemostasis system and a decrease in the level of lipid peroxidation products and the activity of antioxidant blood enzymes under the influence of melatonin. These effects are correlated with the restoration of the electrolyte-water excretory kidneys function indicators. The results of the experiments allow us to consider the appropriate use of the anticoagulants and antioxidants in order to develop methods for the prevention and correction of the toxic effects of chromium compounds on the body

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Keywords: melatonin, chromium, hemostasis, lipid peroxidation, kidney function