Северного Кавказа
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Журнал включён в Перечень ведущих рецензируемых научных журналов и изданий, в которых должны быть опубликованы результаты диссертаций на соискание учёной степени кандидата и доктора наук (решение Президиума ВАК Минобрнауки РФ №6/6, февраль 2010).
Журнал включён в Реферативный журнал и Базы данных ВИНИТИ РАН и зарегистрирован в Научной электронной библиотеке в базе данных Российского индекса научного цитирования на основании сублицензионного договора № 07-04/09-14 от 25 марта 2009 года.
Журнал индексируется: БД SCOPUS, Ulrich's International Periodicals Directory.
Проблемы и перспективы использования оптогенетических технологий в XXI веке
[Обзоры]
Фомочкина Ирина Ивановна; Сорокина Лея Евгеньевна; Петренко Виталина Игоревна; Кучеренко Александр Сергеевич; Халилов С.И. ; Кубышкин Анатолий Владимирович; Субботкин Михаил Владимирович; Куланова Алина Алексеевна;
В XXI веке на пересечении генной инженерии и передовых лазерных технологий развивается новое перспективное научное направление – оптогенетика, в рамках которой разрабатывается обширный арсенал для изучения механизмов функционирования организма, функциональной диагностики и терапии социально значимых заболеваний человечества. В работе представлены современные данные о перспективах использования достижений оптогенетики
для решения широкого круга биомедицинских задач. Обзор содержит описание основных способов доставки, встраивания и контроля экспрессии светочувствительных белков на мембране изучаемых клеток. Дается характеристика физико-технической стороны оптогенетического эксперимента, указываются ключевые преимущества и недостатки различных методик. Описываются основные трудности и нюансы в работе с оптогенетическими технологиями, примеры технических решений для выполнения одновременной оптостимуляции и регистрации клеточной активности.
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Ключевые слова: оптогенетика, опсины, ионные каналы, оптоволоконные системы, фотостимуляция
Учредители:
Ставропольская государственная медицинская академия
Государственный научно-исследовательский институт курортологии
Пятигорская государственная фармацевтическая академия