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https://doi.org/10.14300/mnnc.2020.15015

Ethnic characteristics of antiaggregant action of acetylsalicylic acid in residents of Stavropol territory

[Clinical Pharmacology] [Pharmacology]
Vladimir Baturin; Anna Vladimirovna Ivanova; Konstantin Muravyov; Anna Tsarukyan; Ekaterina Nikolaevna Kolodyazhnaya;

In patients of a cardiology unit receiving acetylsalicylic acid 75 mg per day, laser aggregometry was performed 5 days after the start of treatment. The effect of anti-aggregation therapy was evaluated in the ethnic groups of the slavs (Russians and Ukrainians) and Armenians – residents of the Stavropol Territory. It was established that in the Slavic ethnic group, cases of insufficient effectiveness of acetylsalicylic acid (26 %) were more often detected than among Armenians (9.8 %). Moreover, in 7.3 % of patients in the Slavic ethnic group, according to aggregatometry, the effect of acetylsalicylic acid was not detected at all. There were no such cases among Armenians.

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Keywords: acetylsalicylic acid, resistance, aggregatogram, ethnic characteristics