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Diverticular disease of the colon and its assotiation with polyps and colorectal cancer: a clinical, instrumental and immunomorphological study

[Original research]
Mikhail Osadchuk; Andrey Svistunov; Alexandra Zolotovitskaya; Vladimir Reshetnikov; Vasiliy Kozlov; Ekaterina Dmitrievna Mironova; Maksim Osadchuk; Ekaterina Sergeevna Ogibenina;

Presently the development of early prognostic criteria for the course of diverticular colon disease (DCD) based on proliferation indicators such as Kisspeptin1 (KISS1), p53, chromogranin-A (CgA) is particularly relevant. The aim of the study was to determine the role of clinical endoscopic and immunomorphological parameters in patients with DCD and in combination with adenomatous intestinal polyps (APC) and colorectal cancer (CRC). We examined 190 patients with DCD (120), comorbid to CRC (15) and APC (55), and 28 healthy people. According to the results, the expression of p53 in the DCD group with CRC is higher than the average value in the group of healthy subjects (0.34 and 0.16). Expression of the KISS1 receptor (KISS1R) in individuals with DCD in combination with APC was decreased, while in patients with CRC it was completely absent. CgA expression increased in patients with DCD and reached maximum values in CRC. Thus, DCD and its combination with APC and CRC have both common pathogenetic mechanisms and differences in immunomorphological parameters, and in the number of neuroendocrine cells of the gastric mucosa secreting KISS1R, p53, and CgA.


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Keywords: diverticular disease of the colon, kisspeptin1 (KISS1), p53, chromogranin-A (CgA)

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy