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Clinical course of meningitis caused by Streptococcus Pneumoniae in HIV-positive patients

[Infectious diseases]
Vera Valentinovna Nikolenko; Andrey Valentinovich, Nikolenko; Olga Nikolaevna Sumlivaya; Natalya Nikolaevna Vorobeva; Elena Valerievna Belkina;

Objective: to study the clinical course of meningitis caused by S. pneumoniae in patients with HIV infection. In 2011–2016 clinical and laboratory examination of 172 HIV-infected patients with bacterial purulent meningitis was carried out, the groups of observation (HIV-positive patients) and comparison (HIV-negative patients) with pneumococcal meningitis were formed. It has been established that the clinical variant of the course of the infectious process in HIV-positive patients affected by S. pneumoniae is manifested by significant severity without a pronounced «drop» in blood CD4+ T-lymphocytes. The incidence of neurological disorders and mortality in HIV-positive patients is higher than in the general population.

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Keywords: HIV-positive patients, meningitis caused by Streptococcus pneumoniae


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