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Clinical course of meningitis caused by Streptococcus Pneumoniae in HIV-positive patients

[Infectious diseases]
Vera Valentinovna Nikolenko; Andrey Valentinovich, Nikolenko; Olga Nikolaevna Sumlivaya; Natalya Nikolaevna Vorobeva; Elena Valerievna Belkina;

Objective: to study the clinical course of meningitis caused by S. pneumoniae in patients with HIV infection. In 2011–2016 clinical and laboratory examination of 172 HIV-infected patients with bacterial purulent meningitis was carried out, the groups of observation (HIV-positive patients) and comparison (HIV-negative patients) with pneumococcal meningitis were formed. It has been established that the clinical variant of the course of the infectious process in HIV-positive patients affected by S. pneumoniae is manifested by significant severity without a pronounced «drop» in blood CD4+ T-lymphocytes. The incidence of neurological disorders and mortality in HIV-positive patients is higher than in the general population.

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References:
1. Koroleva I. S., Beloshickij G. V., Koroleva M. A., Zakroeva I. M., Spirihina L. V. [et al.]. Meningokokkovaya infekciya i gnojnye bakterial’nye meningity v Rossijskoj Federacii: desyatiletnee ehpidemiologicheskoe nablyudenie.Epidemiologiya i infektsionnye bolezni. Aktualnye voprosy. – Epidemiology and infectious diseases. Actual issues. 2013;2:15-20. (In Russ.). https://epidemiology-journal.ru/ru/archive/article/11773
2. Thigpen V. C., Whitney C. G., Messonnier N. E., Zell E. R., Lynfield R. [et al.]. Bacterial meningitis in the United States, 1998-2007. N. Engl. J. Med. 2011;36(21):2016-2025.
3. Kostyukova N. N., Bekhalo V. A. Ot bezvrednogo nositel’stva k gnojnomu meningitu. Epidemiologiya i infektsionnye bolezni. Aktualnye voprosy. – Epidemiology and infectious diseases. Actual issues. 2013;2:46-52. (In Russ.). https://epidemiology-journal.ru/ru/archive/article/11779
4. Briko N. I., Simonova E. G., Kostinov M. P., Zhirova S. N., Kozlov R. S., Murav’ev A. A. Immunoprofilaktika pnevmokokkovyh infekcij. M., 2013. (In Russ.).
5. Kozlov R. S. Pnevmokokki: uroki proshlogo, vzglyad v budushchee: monografiya. Smolensk, 2010. (In Russ.).
6. Yin Z., Rice B. D., Waight P., Miller E., George R. [et al.]. Invasive pneumococcal disease among HIV-positive individuals, 2000-2009. AIDS (London, England). 2012;26:87-94.
7. Barlett D., Gallant D., Fam P. Klinicheskie aspekty VICH-infekcii 2009. M.: «R. Valent», 2010. (In Russ.).
8. WHO position paper on pneumococcal vaccines. Weekly epidemiological record. 2012;14:129-144.
9. Belyakova N. A., Rassohina V. V., Stepanova E. V. VICH-infekciya, vtorichnye i soputstvuyushchie zabolevaniya. Tematicheskij arhiv. SPb.: «Baltijskij medicinskij obrazovatel’nyj centr», 2014. (In Russ.).
10. Fel’dblyum I. V., Nikolenko V. V., Vorob’eva N. N., Ivanova E. S., Shmagel’ N. G. [et al.]. Reaktogennost’, bezopasnost’, immunogennost’ i profilakticheskaya ehffektivnost’ polisaharidnoj pnevmokokkovoj vakciny priimmunizacii VICH-inficirovannyh. Zhurnal mikrobiologii, ehpidemiologii i immunologii. – Journal of Microbiology, Epidemiology and Immunology. 2013;3:52-60. (In Russ.).
11. Jordano Q., Falco V., Almirante B., Planes A. M., Valle O. [et al.]. Invasive pneumococcal disease in patients infected with HIV: still a threat in the era of highly active antiretroviral therapy. Clin. Infect. Dis. 2004;38:1623-1628.
12. Grau I., Pallares R., Tubau F., Schulze M. H., Llopis F. [et al.]. Epidemiologic changes in bacteremic pneumococcal disease in patients with human immunodeficiency virus in the era of highly active antiretroviral therapy. Arch. Intern. Med. 2005;165:1533-1540.
13. MacLeod C. M., Krauss M. R., Heidelberg M., Bernhard W. G. Prevention of pneumococcal pneumonia by immunization with specific capsular polisaccharides. J. Exp. Med. 1945;82:445-465.
14. Kroon F. P., van Dissel J. T., de Jong J. C., van Furth R. Antibody response to influenza, tetanus and pneumococcal vaccines in HIV-seropositive individuals in relation to the number of CD4+ lymphocytes. AIDS. 1994;8(4):469.
15. May T., Silverman R. D. Clustering of exemptions as a collective action threat to herd immunity. Vaccine. 2003;21:1048-1051.
16. Herold A. H., Roetzheim R. G., Young D. L., Anderson M. J., Blair R. C., Mockler B. Effect of undocumented and excluded vaccinations on measles immunity in a university population. J. Fla. Med. Assoc. 1993;80:173-177.

Keywords: HIV-positive patients, meningitis caused by Streptococcus pneumoniae


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