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Clinical features of familial cases of paranoid schizophrenia

[Psychiatry]
Elena Kolesnichenko; Yury Dzhangildin; Sergey Ovsyannikov; Sergey Shamov; Yulia Barylnik; Ummurayzat Gadjieva;

We investigated the clinical features of familial cases of paranoid schizophrenia in comparison with sporadic cases of paranoid schizophrenia. The patients with paranoid schizophrenia with a family history of schizophrenia (n=30) and patients with paranoid schizophrenia without family history of schizophrenia (n=140) were examined. The SADS-L «Schizophrenia and Affective Disorders Scale» and «The evaluation list of symptoms and a glossary for mental disorders, ICD-10» was used to assess the psychopathological state and psychopathology symptoms. In most cases, mothers or relatives of probands on the maternal line were the ancestors of the disease. There was no association of familial schizophrenia with the type of disease course (p>0.05). Associations of family schizophrenia with clinical simptoms (p<0.05) were found in the form of a symptom of depersonalization and delusional ideas of persecution. Suicidal intentions and attempts were significantly more common in patients with familial schizophrenia.

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Keywords: paranoid schizophrenia, family schizophrenia, depersonalization, delusions of persecution, suicide


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