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Antioxidant and hemolytic properties of different extracts from Prunella vulgaris L. leaves

[Clinical Pharmacology] [Pharmacology]
Agapi Ohanyan; Nona Shishkoyan; Shushanik Kazaryan; Ashkhen Hovhannisyan; Susanna Tiratsuyan; Karine Elbekyan; Vladimir Koshel; Anna Khodzhayan;

The plant Prunella vulgaris L. has long been used in traditional European and Asian medicine. Its extracts reveal immunoprotective, antitumor, antiinflammatory, and antiestrogenic features. We obtained aqueous and ethanol extracts from P. vulgaris L. leaves; carried out HPLC analysis; detected the total flavonoids content and the antiradical activity. The effect of different extracts of Prunella vulgaris L. on the activity of superoxide dismutase of healthy donors’ erythrocytes was studied. It was shown that the major component of ethanol extracts is rosmarinic acid. 50 % ethanol extract of P. vulgaris features high antiradical, antioxidant (SOD) and low hemolytic activity.


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Keywords: Prunella vulgaris L. extracts, total flavonoid content, HPLC analysis; antiradical activity, erythrocytolysis, SOD

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy