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Morphological fundamental of neurogeneous mechanisms of sudden infant death syndrome

[Reviews]
Margarita Berlay; Anatolii Kopylov; Sergei Karpov; Horen Avanesyan;

The «Sudden Infant Death Syndrome» is a heterogeneous phenomenon, represented by respiratory, cardiac, genetic, immuno-endocrine components. The importance of understanding the neurogenic mechanisms of the emergence of this syndrome as a manifestation of the pathology of the brain stem structures is emphasized. Attention is drawn to the necessity of a qualified autopsy study with a a careful analysis of medical records, the circumstances of death and an extended sampling of fragments of the central and peripheral nervous system for additional immunohistochemical examination.

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References:
1. Erofeev S. V., Edelev N. S., Malakhov N. V., Semenov A. S. The problem of expert evaluation of the unfavorable outcome of medical care: monitoring, development and current status. Sudebnaya-meditsina. Nauka. Praktika. Obrazovaniye. – Forensic medicine. Science. Practice. Education. 2017;3(1):4-10. (In Russ.). https://doi.org/10.19048/2411-8729-2017-3-1-4-10
2. Bokeria L. A., Bokeria O. L., Kulaga O. I. Syndrome of sudden death of newborns: etiology, pathogenesis, modern diagnostic approaches and methods of prevention. Annaly aritmologii. – The annals of Arrhythmology. 2009(2):12-23. (In Russ.).
3. Kravtsova L. A. Modern aspects of the syndrome of sudden death of infants. Ross. vest. perinatol. pediatrii. – The Russian Bulletin of Perinatology and Pediatrics. 2010;55(2):60-68. (In Russ.).
4. Lavezzi A. M., Ferrero S., Roncati L.,Matturri L., Pusiol T. Impaired orexin receptor expression in the Kölliker-Fuse nucleus in sudden infant death syndrome: possible involvement of this nucleus in arousal pathophysiology. Neurol. Res. 2016;38(8):706-716.
5. Glukhovets B. I. Syndrome of sudden death of infants: methodological and pathogenetic variants of diagnosis. Voprosy sovremennoj pediatrii. – Issues of modern Pediatrics. 2011;10(2):78-82. (In Russ.).
6. Garstang J., Ellis C., Sidebotham P. An evidence-based guide to the investigation of sudden unexpected death in infancy. Forensic Sci. Med. Pathol. 2015;11(3):345-357.
7. Friedmann I., Dahdouh E. M., Kugler P., Mimran G., Balayla J. Maternal and obstetrical predictors of sudden infant death syndrome (SIDS). J. Matern. Fetal. Neonatal. Med. 2016;24:1-9.
8. Ariagno R. L., van Liempt S., Mirmiran M. Fewer spontaneous arousals during prone sleep in preterm infants at 1 and 3 months corrected age. Journal of Perinatology. 2006;26:306-312.
9. Lavezzi А. М. A New Theory to Explain the Underlying Pathogenetic Mechanism of Sudden Infant Death Syndrome. Front. Neurol. 2015;6:220. https://doi.org/10.3389/fneur.2015.00220
10. Hauck F. R., Tanabe K. O. International trends in sudden infant death syndrome: stabilization of rates requires further action. Pediatrics. 2008;122:660-666.
11. Rubens D., Sarnat H. B. Sudden infant death syndrome: an update and new perspectives of etiology. Handb. Clin. Neurol. 2013;112:867-874. https://doi.org/10.1016/ B978-0-444-52910-7.00008-8
12. Matturri L., Ottaviani G., Lavezzi A. M. Guidelines for neuropathologic diagnostics of perinatal unexpected loss and sudden infant death syndrome (SIDS): a technical protocol. Virchows Arch. 2008;452(1):19-25.
13. Moon R. Y. SIDS and Other Sleep-Related Infant Deaths: Evidence Base for 2016 Updated Recommendations for a Safe Infant Sleeping Environment. Pediatrics. 2016;138(5).
14. Mage David T., Latorre Maria Luisa, Jenik Alejandro G., Donner E. Maria. An Acute Respiratory Infection of a Physiologically Anemic Infant is a More Likely Cause of SIDS than Neurological Prematurity. Front. Neurol. 2016(7):129. https://doi.org/10.3389/fneur.2016.00129
15. Spinelli J., Collins-Praino L., Van Den Heuvel C., Byard R. W. Evolution and significance of the triple risk model in sudden infant death syndrome. J. Paediatr. Child. Health. 2016. https://doi.org/10.1111/jpc.13429
16. Carlin R. F., Moon R. Y. Risk Factors, Protective Factors and Current Recommendations to Reduce Sudden Infant Death Syndrome: A Review. JAMA Pediatr. 2016. https:// doi.org/0.1001/jamapediatrics.2016.3345
17. Ramirez S., Allen T., Villagracia L., Chae Y., Ramirez J. M., Rubens D. D. Inner ear lesion and the differential roles of hypoxia and hypercarbia in triggering active movements: Potential implication for the Sudden Infant Death Syndrome. Neuroscience. 2016;337:9-16.
18. Cappiello A., Famiglini G., Palma P., Termopoli V., Lavezzi A. M., Matturri L. Determination of selected endocrine disrupting compounds in human fetal and newborn tissues by GC-MS. Anal. Bioanal. Chem. 2014;406(12): 2779-2788.
19. Roncati L., Termopoli V., Pusiol T. Negative Role of the Environmental Endocrine Disruptors in the Human Neurodevelopment. Front. Neurol. 2016;7:143.
20. Huang W. T., Chen R. T., Hsu Y. C., Glasser J. W., Rhodes P. H. Vaccination and unexplained sudden death risk in Taiwanese infants. Pharmacoepidemiol. Drug. Saf. 2017;26(1):17-25.
21. Ali K., Rosser Т., Bhat R., Wolff K., Hannam S., Rafferty G.F., Greenough A. Antenatal smoking and substancemisuse, infant and newborn response to hypoxia. Pediatr. Pulmonol. 2016. https://doi.org/0.1002/ppul.23620
22. Garcia Alfredo J., Koschnitzky Jenna E., Ramireza Jan-Marino. The physiological determinants of Sudden Infant Death Syndrome. Respir. Physiol. Neurobiol. 2013;189(2). https://doi.org/10.1016/j.resp. 2013.05.032
23. Schwender K., Holtkötter H., Johann K. S., Glaub A., Schürenkamp M., Sibbing U., Banken S., Vennemann M. Sudden infant death syndrome: exposure to cigarette smoke leads to hypomethylation upstream of the growth factor independent 1 (GFI1) gene promoter. Forensic. Sci. Med. Pathol. 2016;12(4):399-406.
24. Zakharova E. A., Selikhova M. S. The correlation between the clinical and social determinants of an undeveloped pregnancy. Medicinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2017;12(1):58-60. (In Russ.). https://doi.org/10.14300/mnnc.2017.12015
25. McDonald F. B., Chandrasekharan K., Wilson R. J., Hasan S. U. Cardiorespiratory control and cytokine profile in response to heat stress, hypoxia, and lipopolysaccharide (LPS) exposure during early neonatal period. Physiol. Rep. 2016;4(2). https://doi.org/10.14814/phy2.12688/ pii:e12688
26. Bugaev D. A., Gorbunkov V. Ya. Selected issues of monitoring and ensuring the quality of care. Medicinskii vestnik Severnogo Kavkaza. – Medical News of North Caucasus. 2016;11(3):483-488. (In Russ.). https://doi.org/10.14300/mnnc.2016.11113
27. Vorontsov I. M, Kelmanson I. A., Tsinzerling A. V. Sindrom vnezapnoy smerti grudnykh detey. SPb.: «SpetsLit», 1997. (In Russ.).
28. Oehmichen M., Written B., Zilles K., Saternus K. S. Cytological investigations on the cerebellar cortex of sudden infant death victims. Acta Neuropathol. 1989;78(4): 404-410.
29. Kinney H. C., Poduri A. H., Cryan J. B., Haynes R. L., Teot L., Sleeper L. A., Holm I. A., Berry G. T., Prabhu S. P., Warfield S. K., Brownstein C., Abram H. S., Kruer M., Kemp W. L., Hargitai B., Gastrang J., Mena O. J., Haas E. A., Dastjerdi R., Armstrong D. D., Goldstein R. D. Hippocampal Formation Maldevelopment and Sudden Unexpected Death across the Pediatric Age Spectrum. J. Neuropathol. Exp. Neurol. 2016;75(10):981-997.
30. Paine S. M., Jacques T. S., Sebire N. J. Review: Neuropathological features of unexplained sudden unexpected death in infancy: current evidence and controversies. Neuropathol. Appl. Neurobiol. 2014;40(4):364-384. https://doi.org/10.1111/nan.12095
31. Thach B. T. Potential Central Nervous System Involvement in Sudden Unexpected Infant Deaths and the Sudden Infant Death Syndrome. Compr. Physiol. 2015;5(3): 1061-1068.
32. Kim K. K., Adelstein R. S., Kawamoto S. Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors. J. Biol. Chem. 2009;284:31052-31061.
33. Sukhorukova E. G., Kirik O. V., Zelenkova N. M. Neuronal nuclear antigen NeuN is an indicator of the integrity of the nervous tissue and its suitability for immunohistochemical examination. Meditsinsky akademichesky zhurnal. – Medical academic journal. 2015;15(1):63-67. (In Russ.).
34. Szuhany Kristin L., Bugatti Matteo, Otto Michael W. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. Journal of Psychiatric Research. 2015;60:56-64. https://doi.org/10.1016/j.psychires.2014.10.003
35. Hunt N. J., Waters K. A., Machaalani R. Promotion of the Unfolding Protein Response in Orexin/Dynorphin Neurons in Sudden Infant Death Syndrome (SIDS): Elevated pPERK and ATF4 Expression. Mol. Neurobiol. 2016. Oct. 29.
36. Parilov S. L., Bubnova N. I., Klevno V. A. Sudebno-medicinskaja diagnostika i ocenka cherepnomozgovyh i sochetannyh rodovyh travm nervnoj sistemy u novorozhdennyh i detej pervogo goda zhizni. M., 2009. (In Russ.).
37. Graham S. F., Chevallier O. P., Kumar P., Türko Gcaron Lu. O., Bahado-Singh R. O. Metabolomic profiling of brain from infants who died from Sudden Infant Death Syndrome reveals novel predictive biomarkers. J. Perinatol. 2017;37(1):91-97.
38. La Grange H., Verster J., Dempers J. J., de Beer C. Review of immunological and virological aspects as contributory factors in Sudden Unexpected Death in Infancy (SUDI). Forensic Sci. Int. 2014;245:12-16.
39. Mitchell E. A., Krous H. F. Sudden unexpected death in infancy: a historical perspective. Pаediatr. Child. Health. 2015;51(1):108-112. https://doi.org/10.1111/ jpc.12818
40. Weber M. A., Risdon R. A., Ashworth M. T., Malone M., Sebire N. J. Autopsy findings of co-sleeping-associated sudden unexpected deaths in infancy: relationship between pathological features and asphyxial mode of death. J. Paediatr. Child. Health. 2012;48(4):335-341.

Keywords: sudden infant death syndrome, heterogeneous, immunohistochemical examination of the brain stem


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