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https://doi.org/10.14300/mnnc.2018.13050

The study of Arg25Pro polymorphism gene of transforming growth factor β1 in children with bronchial asthma

[Pediatrics]
Alexander Lebedenko; Tatiana Shkurat; Elena Mashkina; Olga Semernik; Tatiana Drejzina;

Objective: to study the role of polymorphism of Arg25Pro gene TGFβ1 in the pathogenesis of asthma in children. We studied the association of Arg25Pro polymorphism of the TGFβ gene with the risk of developing asthma in children. The results of the genetic analysis are compared with the content of TGFβ1 in the blood serum of patients. When studying the Arg25Pro polymorphism of the TGFβ1 gene, it was noted that among the examined patients homozygotes over the Arg25 allele predominate. The frequency of heterozygotes Arg25Pro among the group of children suffering from asthma is 3.08 times lower in comparison with healthy children. The association of polymorphism of Arg25Pro gene TGFβ1 with an increased risk of asthma in children has been established. It was shown that in patients with the ArgArg genotype of the TGFβ1 gene, the concentration of TGFβ1 in the blood serum was increased (132.08±77.28 pg/ml), compared with heterozygotes (88.47±86.26 pg/ml) or patients with ProPro genotype (94.77±92.48 pg/ml).
The association of the Arg25Pro polymorphism of the TGFβ1 gene with an increased risk of developing asthma in children has been established. The relationship of this gene polymorphism with increased synthesis of TGFβ1 is shown.

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Keywords: bronchial asthma, children, gene, polymorphism, transforming growth factor β1 (TGFβ1)