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[Clinical Pharmacology] [Pharmacology]
Olga Kaminskaya; Eduard Beyer; Eduard Arushanyan;
Pineal hormone melatonin (0.5 mg/kg), fluoxetine (5 mg/kg) and their combination were studies on model of reserpine-induced depression in rats. Experiments were performed in the «open field» test, reserpine-induced ptosis and hypothermia. As was shown melatonin, less than fluoxetine, could antagonize reserpine-induced depression. In combination with fluoxetinemelatonin potent it antidepressant-like effects.
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Keywords: reserpine depression, melatonin, fluoxetine, combination