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of the North Caucasus
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ISSN 2073-8137

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Assesment of the action of melatonin and fluoxetine on the model of resinpina depression

[Clinical Pharmacology] [Pharmacology]
Olga Kaminskaya; Eduard Beyer; Eduard Arushanyan;

Pineal hormone melatonin (0.5 mg/kg), fluoxetine (5 mg/kg) and their combination were studies on model of reserpine-induced depression in rats. Experiments were performed in the «open field» test, reserpine-induced ptosis and hypothermia. As was shown melatonin, less than fluoxetine, could antagonize reserpine-induced depression. In combination with fluoxetinemelatonin potent it antidepressant-like effects.


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Keywords: reserpine depression, melatonin, fluoxetine, combination

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy