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Role of pro-inflammatory neuropeptides at ulcerative colitis
[Original research] [Internal diseases]
Vladimir Pavlenko; Svetlana Alexandrova; Elizaveta Tsurova; Leila Amirkhanova;
The study included 40 patients with ulcerative colitis in the dynamics of treatment with various combinations of drugs. Neuropeptides content in serum was determined by ELISA.
It was found that in acute condition of ulcerative colitis P content was increased in the blood serum and the level of NT was reduced. The content of SP in serum was in direct proportion to the severity of the disease and the level of NT was in inverse proportion.
Drugs used in the treatment of ulcerative colitis can modulate the level of neuropeptides studied in serum of patients with active ulcerative colitis.
References:
1. Bakulin I. G., Stanke D. A., Belousova Ye. A., Mikhaylova T. L. Eksperimentalnaya klinicheskaya gastroenterologiya. 2008; 6:14–16.
2. Beloborodova E. I., Burkovskaya V. A., Markidonova A. A. Sibirsky meditsinsky zhurnal. 2012; 3:136–138.
3. Khalif I. L., Loranskaya I. D. Miklosh 2004:88
4. Galeyeva Z. M. Vestnik sovremennoy klinicheskoy meditsiny. 2010;2(3):47–50.
5. Ivashkina V. T., Lapinoy T. L. GEOTAR-Media. 2008;70
6. Vorobyeva G. I., Khalifa I. L. Miklosh. 2008;400
7. Komarov F. I. , Osadchuk A. M. , Osadchuk M. A., Kvetnoy I. M. OOO «Meditsinskoye informatsionnoye agentstvo». 2008;256
8. Brun P., Mastrotto C., Beggiao E. Physiol. Gastrointest Liver Physiol. 2005; 288: 621–629.
9. Neunlist M. Gut. 2003; 52:84–90.
10. Fiebich B. L., Schleicher S., Immunol J. 2000;165:5606–5611.
11. M. V. Gandhu .Gut. 2007;56:358–364.
12. Kara J., Gross M. D., Charalabos M. D. Inflammatory Bowel Diseases. 2007;13:918–932.
13. Karagiannides I. Proc Natl Acad Sci USA. 2006;103:5207–5212.
14. Koon H. W., Pothoulakis C. N.Y. Ann. Acad. Sci. 2006;10:23–40.
15. Riddell R. H., Kirsner J. B. Inflammatory Bowel Disease. W. B. Saunders company, Philadelphia. 2000
16. W. P. ter Beek, Biemond I. Neuropeptides. 2007;41:301–306.
17. Hansen M. B. Pharmacology & Toxicology. 2003;93:1–13.
18. Wehkamp J., Feller mann K., Herrlinger K. R. Nat. Clin. Pract. Gastroenterol. Hepatol. 2005; 2:406–415.
Keywords: ulcerative colitis, neuropeptides
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy