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of the North Caucasus
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Series ПИ #ФС 77-26521.
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ISSN 2073-8137

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Asthma symptoms in children with connective tissue disorders: clinical features, complications

[CTD in pediatrics]
Zoya Nesterenko;

The aim was to study clinical course and complications of bronchial asthma in children with connective tissue dysplasias (CTD).

Objects were 118 children with asthma aged 1–18 years. CTD was recognized in 80% of patients: unclassified CTD phenotype – in 68.1%, Ehlers-Danlos-like CTD phenotype – in 20.8% and Marfan-like phenotype – in 11.1% of children. Community-acquired pneumonia (CAP), diagnosed in 29.7% of asthmatic patients, significantly prolonged respiratory symptoms of asthma. Strong positive correlation between the CAP and Ehlers-Danlos-like and Marfan-like CTD phenotypes frequency was found (rxy>0,9). Pulmonary hypertension was determined as the most common asthma complication in children with CTD manifestations. Pulmonary fibrosis identified in 50% and bullae emphysematous – in 30% of these patients. Strong positive correlation (rxy>0,9) of the asthma complications and severity of CTD manifestations (Ehlers-Danlos-like and Marfan-like CTD phenotypes) was revealed. The involvement of several systems of organs in the pathological process in patients with asthma and CTD significantly complicates early diagnosis of asthma and worsens the prognosis. The revealed clinical features of asthma in children with CTD signs can reduce diagnostic errors.


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Keywords: children, bronchial asthma, connective tissue dysplasia

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy