Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 8652 352524; +7 8652 353229.

+7 8652 352524.


Pathomorphological changes of dental pulp in experimental osteoporosis

[Experimental medicine]
Sergey Sirak; Evgeny Shchetinin; Alla Sirak; Ivan Koshel; Magomet Aybazov; Marina Vafiadi; Anatolii Adamchik;

The study focused on pathomorphological changes taking place in the tooth pulp in sheep in case of experimental osteoporosis. The pulp was extracted after cracking the teeth. The sections were stained with hematoxylin and eosin by Masson, and impregnated with silver by Foot and Bielschowsky-Gros. There were severe vascular disturbances detected (vasodilation, stasis, perivascular edema with cell infiltration, hemorrhages), which resulted in vacuolization of odontoblasts, pulp reticular dystrophy, disintegration of argyrophilic and nerve structures. Such disturbances came along with proliferation of cell elements in the connective tissue and in nerve elements with denticle development.


1. Goldberg M., Farges J.-C., Lacerda-Pinheiro S. Inflammatory and immunological aspects of dental pulp repair. Pharmacological Research. 2008;58(2):137-147. doi: 10.1016/j.phrs.2008.05.013
2. Kanis J. A., McCloskey E. V., Johansson H. European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporosis International. 2013;24(1):23-57. doi: 10.1007/s00198-012-2074-y
3. Manolagas S. C., Jilka R .L. Mechanisms of disease: Bone marrow, cytokines, and bone remodeling – Emerging insights into the pathophysiology of osteoporosis. New England Journal of Medicine. 1995;332(5):305-311. doi: 10.1056/NEJM199502023320506
4. Ohshima H. Oral biosciences: The annual review 2015. Journal of Oral Biosciences. 2016;58(1):1-9. doi:10.1016/j.job.2015.12.001
5. Shchetinin E. V., Sirak S. V., Khodzhayan A. B. Pathogenetic aspects of dental pulp pathology. Medical News of North Caucasus. 2015;10(2):187-191. doi: 10.14300/mnnc.2015.10044
6. Sirak A. G., Sirak S. V. Morfofunkcionalnie izmeneniya v pulpe zubov eksperimentalnich zhivotnich pri lechenii glubokogo kariesa. Sovremennie problemi nauki i obrazovaniya.– Modern problems of science and education. 2013;2:44.
7. Sirak S. V., Bykov I. M., Sirak A. G., Akopova L. V. Profilaktika kariesa i vospalitelnich zabolevaniy parodonta s ispolzovaniem zubnich eliksirov. Kubanskiy nauchniy medicinskiy vestnik – Kuban scientific medical bulletin. 2013;6:166-169.
8. Tella S. H., Gallagher J. C. Prevention and treatment of postmenopausal osteoporosis. Journal of Steroid Biochemistry and Molecular Biology. 2014;142:155-170. doi: 10.1016/j.jsbmb.2013.09.008

Keywords: osteoporosis, pulp, experiment, odontoblasts

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy