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ISSN 2073-8137
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Levels of neurotropic autoantibodies in patients with schizophrenia

[Psychiatry]
Vladimir Baturin; Mariya Baturina; Galina Mamceva; Oleg Boev; Vladimir Yarovitsky;

Plasma levels of IgG autoantibodies to the NMDA-receptors, human S-100 protein, and dopamine Type 2 receptors were detected in 26 males suffering from schizophrenia. Half of the patients had their levels of autoantibodies to the NMDA-receptors above average values, while in the rest of the group the antibody level was within norm. Following that, the patients were divided into two groups: Group 1 with a higher level of antibodies to the NMDA-receptors, Group 2 – with their normal levels of antibodies to the NMDA-receptor. The patients in the Group 1 also revealed significantly elevated levels of autoantibodies to the dopamine Type 2 receptors as well as to the S-100 protein in their blood plasma. Psychometric testing involving the PANSS scale showed that the positive symptoms’ values in the Group 1 were below those in the Group 2 while the negative symptoms’ values in the Group 1 were higher. Respectively, the composite index, which is determined as the difference between the positive and the negative scores, was lower in the Group 1 and higher in the Group 2.

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Keywords: schizophrenia, autoantibodies, NMDA-receptors, dopamine receptors, S-100 protein


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