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IP-10 protein at chronic hepatitis C and its role in forecasting treatment outcomes

[Original research] [Internal diseases]
Natalya Geyvandova; Andrey Lipov; Alexandr Yagoda; Anastasia Frolova;

Clinical values were identified for serum levels of g interferon-induced protein (IP 10) to be employed in forecasting SVR to AVT for CHC, which was carried out involving 107 patients (50 females and 57 males); mean age – 43.0±11 yrs. 75 of the patients were diagnosed with genotype 1 HCV (G1), while 32 patients were identified as having non-1 genotype HCV (G2 or G3). The IP-10 levels in blood serum were detected with the ELISA method. Patients with CHC had significantly higher blood IP-10 levels compared to healthy people, and that depended on the aminotransferases’ activity as well as on the stage of hepatic fibrosis. A standard AVT with pegIFN-α medications and ribavirin given to 52 patients with G1 (SVR 54.9 %) and 27 – with G2 or G3 (SVR 75 %), showed that the patients who had reached SVR had their initial levels of IP-10 below that of non-responders. The prognostic level of IP-10 was detected, above which the likelihood of ending up at SVR in case of AVT with pegIFN-α and ribavirin was questionable: ≤ 403 pg/ml for G1 and ≤ 433 pg/ml for G2 or G3. In 18 patients who were given triple AVT – pegIFN-α + ribavirin + viral proteases inhibitors (SVR – 77.7 %) the initial levels of IP-10 at various outcomes of AVT were the same. Therefore, in case of CHC, the levels of blood IP-10 are elevated and depend on cytolysis activity and the degree of hepatic fibrosis. The levels of IP-10 protein in case of CHC may be used as a predictor regarding the standard AVT outcomes.

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Keywords: chronic hepatitis C, chemokines, antiviral therapy, prognosis


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