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https://doi.org/10.14300/mnnc.2015.10098

Comparative evaluation of acute toxicity doxorubicin and its in niosomes

[Clinical Pharmacology]
Igor Bazikov; Eduard Beyer; Vera Lukinova; Alexander Maltsev;

The range of endurable, toxic and lethal doses of niosomal and standard forms of antitumor antibiotic doxorubicin was investigated. It was administered to laboratory animals intraperitoneally. It was found that the LD50 of doxorubicin in niosomes was 5,5±0,7 in rats and 4,0±0,6 mg/kg for mice of both sexes. In the animals treated with the usual form of the antibiotic, this index was higher – 14,2±1,2 mg/kg and 10,8±1,0 mg/kg, respectively. There are minor gender differences in the sensitivity of animals to test drug. For male rats and mice LD50 values were slightly higher than for females, but these data were not beyond false trends.

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Keywords: doxorubicin, niosomes, acute toxicity