Medical news
of the North Caucasus
Scientific journal
Mass media registration certificate dated December 7, 2006.
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137

Site search

Correspondence address
310 Mira Street, Stavropol, Russia, 355017

+7 8652 352524; +7 8652 353229.

+7 8652 352524.


The influence of experimental hypocalcemia on hemodynamic manifestations of copper intoxication

[Experimental medicine]
Vadim Brin; Karmen Mitziev; Astan Mitziev; Oleg Kabisov;

Copper belongs to the essential trace elements, but an excess of it leads to the development of morphological and functional changes of the internal organs. Most sensitive to the toxic effects of copper is the cardiovascular system. It is known that calcium is a competitive biometals for xenobiotics and artificial condition of hypercalcemia, is used to prevent the toxic effects of heavy metals. However, work on the study of the cardiovascular effects of copper toxicity in terms of hypocalcemia not. Because of this, the aim was to study the effect of copper toxicity on the functional state of the cardiovascular system. A study of the functional state of the cardiovascular system is to identify the main hemodynamic and reactivity of the renin-angiotensin system and adrenoreactivity cardiovascular system. As a result of experimental studies have shown that prolonged delivery copper in the body leads to the development of hypertension and reduce the performance of the pumping functions of the heart. Experimental condition hypocalcemia, promotes a more pronounced toxic effects of copper sulfate on the cardiovascular system.


1. Amerhanova Sh. K., Shljapov R. M., Golovanova O. A., Uali A. S. Vestnik Omskogo universiteta. – Bulletin of Omsk University. 2015;1 (75):46-50.
2. Brin V. B. Zonis B. Ja. Fiziologija sistemnogo krovoobrashhenija. Rostov-na-Donu: «Izdatelstvo Rostovskogo universiteta»; 1984: Р. 1-80.
3. Brin V. B., Mitciev K. G., Mitciev A. K., Kabisov O. T. Vestnik novyh medicinskih tehnologij. – Bulletin of new medical technologies. 2014; 21 (2):83-86.
4. Mitciev K. G., Mitciev A. K., Brin V. B., Kabisov O. T. Kubanskij nauchnyj medicinskij vestnik. – Kuban Research Medical Gazette. 2012; (4):175-178.
5. Pat. 2364947. MPK7 G 09, B 23 28. Sposob modelirovanija hronicheskoj toksicheskoj arterialnoj gipertonii i kardiopatii. Mitciev A. K., Brin V. B., Kabisov O. T.; zajavitel i patentoobladatel GOU VPO SOGMA Minzdravosrazvitija Rossii. – № 2008114661/14; zajavl. 14.04.2008; opubl. 20.08.2009.
6. Brewer G. J. Clinical Neurophysiology. 2010;121(4):459-460. doi: 10.1016/j.clinph.
7. Li S., Case A. J., Yang R. F., Schultz D. H., Zimmerman M. C. Redox Biol. 2013; (2):8-14. doi: 10.1016/j.redox. 2013.11.002.
8. Lukaski H. C. Klevay L. M., Milne D. B. Eur. J. Appl. Physiol. Occup. Physiol. 1988;58 (1-2):74-80.
9. Mata Y. N., Blаzquez M. L., Ballester A., Gonzalez F., Munoz J. A. J. Hazard. Mater. 2009;163 (2-3):555-562. doi:10.1016/j.jhazmat.2008.07.015.
10. Poulsen S. B. Svendsen J. C., Aarestrup K., Malte H. J. Fish. Biol. 2014;84 (5):1326-1339. doi: 10.1111 / jfb.12356.
11. Uriu-Adams J. Y., Keen C. L. Mol. Aspects. Med. 2005;26(4-5):268-298.

Keywords: cardiovascular system, hypocalcemia, copper sulfate, a rat

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy