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Intracellular adhesion molecules and histological pattern in chronic viral liver diseases

[Original research] [Internal diseases]
Pavel Koroy; Irina Mukhoramova; Alexandr Yagoda;

Serum levels of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were studied in 50 patients with chronic viral liver diseases in view of hepatic histo- logical changes.

The patients with chronic viral hepatitis demon- strated higher levels of intercellular adhesion molecule-1 in the blood while an increase in the serum levels of the two adhesion molecules was observed in the cases with liver cirrhosis.

The blood levels of ICAM-1 and VCAM-1 under chronic viral liver diseases increases along with a growing intensity of hepatic steatosis, inflammation and fibrosis. The association of morphological changes in the liver with the mediators of intercellular interactions proves their important role in occurrence and development of chronic viral liver diseases.

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Keywords: chronic viral hepatitis, liver cirrhosis, intercellular adhesion molecule-1, vascular cell adhesion molecule-1


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