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https://doi.org/10.14300/mnnc.2026.00011

Characteristics of morphological changes in pinealocytes during dark deprivation in female rats

[Experimental medicine]
Larisa Kondakova; Svetlana Kalashnikova;

Morphological changes in the pineal gland and the expression of caspase-3 and Klotho protein were studied under conditions of dark deprivation and correction by exogenous melatonin. The work was performed on 4-month-old laboratory rats (n=18) on the background of 30-day dark deprivation. Analysis of pinealocytes showed a relationship between the expression of caspase-3, the Klotho protein, and the morphological characteristics of pinealocytes. A decrease in Klotho protein expression and an increase in the expression of caspase-3 in pinealocytes were revealed. At the same time, the abolition of dark deprivation and the administration of exogenous melatonin for 2 weeks increased Klotho protein expression and decreased caspase-3 expression in pinealocytes.

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Keywords: pineal gland, melatonin, pinealocytes, dark deprivation