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https://doi.org/10.14300/mnnc.2025.20028

Complex interactions between systemic and genetic factors in the adaptation of young men from the North Caucasus

[Original research] [Pediatrics]
Ludmila Tsaturian; Tovmasyan Vardan Erikovic; Tabunshchikova Margarita Olegovna;

The study examined the specific features and relationships of key functional and molecular-genetic factors in young men representing diverse linguistic groups residing in the mid-highland region of the North Caucasus. A total of 62 healthy males aged 17–21 were examined and classified, based on questionnaires and linguistic self-identification, into two groups: Indo European (n=32) and North Caucasian (n=30). The comprehensive assessment included anthropometric measure ments; biochemical analyses (lipid profile, homocysteine); hematological and coagulation parameters; heart rate variability; and molecular-genetic markers of hemostasis (F1, F2, F5, F7, F13A1, ITGA2-A2, ITGB3, PAI-1).

There have been significant differences revealed between the groups in terms of a few metabolic, hematological, and coagulation parameters. The Indo-European group features a predominance of atherogenic and prothrombotic status, while the North Caucasian group demonstrated a combination of cardioprotective and prothrombotic features. This points at certain ethnicity-specific patterns of integration among metabolic, hematological, and genetic factors in young men coming from the North Caucasus region. These features may help inform the design of preventive and screening programs aimed at preserving youth health in the context of ethnic and geographic diversity.

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Keywords: lipid status, homocysteine, blood system, genetic polymorphism of the hemostasis system, ethnicity, young men, correlation analysis, systematic approach