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https://doi.org/10.14300/mnnc.2025.20024

Assessment of cognitive impairments in Women with breast cancer following chemotherapy

[Original research] [Oncology]
Sergei Karpov; Tambieva Khava Karim-Sultanovna; Irina Vishlova; Arsen Koychuev; Anastasia Igorevna Raevskaya; Govorov Andrey Vasilievich;  Karpov Artem Sergeevich; Sultanbekova Milana Alibekovna;

An analysis of global statistics indicates a yearly increase in the number of patients with breast cancer (BC). Fifty-three women aged 31 to 57 years with a confirmed diagnosis of BC undergoing chemotherapy (CTx) were examined to assess cognitive function. All participants underwent clinical-neurological and neurophysiological evaluations to diagnose cognitive impairment. The patients were divided into two groups: Group 1 included patients who had received three courses of CTx, and Group 2 included patients who had received six courses of CTx. A persistent decline in cognitive function was observed in BC patients compared to the control group, as measured by the MoCA test and neurophysiological parameters. Repeated courses of CTx in BC patients resulted in a statistically significant (p<0.001) impairment of cognitive function, underscoring the need for neuroprotective therapy in this patient population.

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Keywords: breast cancer, cognitive functions, chemotherapy, outcomes