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EBSCO

https://doi.org/10.14300/mnnc.2024.19036

Combined hepatoprotective therapy for experimental alcoholic liver damage

[Experimental medicine]
Galina Ermakova; Konstantin Popov; Ilya Bykov; Igor Tsymbalyuk; Anna Germanovna Zavgorodnyaya; Mikhail Bykov; Aleksej Stanislavovich Shevchenko;

This paper offers a view at an experimental assessment of the effectiveness of combined hepatoprotective therapy employed for alcoholic liver damage treatment using sulfur-containing drugs. The study involved five groups of rats: Group 1 – intact rats; Group 2 – animals subjected to alcoholism for two months, with no correction carried out; Groups 3, 4 and 5 were rats that were given ademetionine (10 mg/100 g/day), lipoic acid (10 mg/100 g/day) and combined, respectively.

The studies showed that the AST and LDH activity in the animals’ blood plasma in Group 5 was 16 % and 42 % below similar indicators of Group 2 only, yet also statistically reliably lower than the values of similar indicators in the animals in Groups 3 and 4. Combined use of ademetionine and lipoic acid came along with relatively low values of the total antioxidant activity, which was 32–40 % below that in control. Yet, it allowed the weakest levels of product accumulation to be arrived at through oxidative modifications of biomolecules.

The level of thiobarbituric acid reactive substances (TBA-reactive substances) measured in the blood of rats in Group 5 was 46 % lower than the corresponding marker value in Group 2 and 36–40 % lower than the values of similar indicators measured in the animals belonging to Group 3 and 4. The obtained data proved a higher efficiency of combined hepatoprotective therapy involving ademetionine and lipoic acid than monotherapy using respective drugs.

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Keywords: ethanol, alcoholic hepatitis, antioxidants, hepatoprotectors, lipoic acid, ademetionine