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https://doi.org/10.14300/mnnc.2024.19035

Results of exposure of endogenous antimicrobial peptides to ESKAPE-pathogens in experiment

[Experimental medicine]
Igor Bazikov; Alexander Maltsev; Anna Efremenko; Valentina Botasheva; Filipp Bazikov; Ramesh Goyal; Nazirul Amin Amijahan;

The effectiveness of the developed niosomal forms of endogenous defensins in their effect on ESKAPE-pathogens was studied experimentally. Histological studies of the wound healing process revealed that when wounds were infected with an antibiotic resistant strain of S. aureus, external use of solutions with endogenous alpha and beta defensins had a more pronounced therapeutic effect than control groups. Elimination of ESKAPE-pathogens, a study of the linear rate of wound healing and wound area, also indicated that using the niosomal form of endogenous defensins significantly accelerated epithelialization, starting from the first days of the experiment, compared with traditional antimicrobial drugs.

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Keywords: antimicrobial peptides, antibiotic resistance, histological changes, wound healing