of the North Caucasus
Series ПИ #ФС 77-26521.
Federal service for surveillance over non-violation of the legislation in the sphere of mass communications and protection of cultural heritage.
ISSN 2073-8137
русский
english
Site search
Correspondence address
310 Mira Street, Stavropol, Russia, 355017
Tel
+7 865 2352511, +7 865 2353229.
E-mail
medvestnik@stgmu.ru
The journal is included into The list of leading scientific periodicals.
The journal is included into VINITI database and is registered in Electronic scientific library.
The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.
Urea synthesis in the liver of mice after skeletal injury on the background of amino acid load
[Experimental medicine]
Maxim Valerievich Stogov; Elena Anatolyevna Kireeva;
The dynamics of the urea level in the liver of mice after skeletal injury in the presence of additional amounts of amino acids leucine, isoleucine, arginine and methionine with food was studied. The study was performed on 74 male mice of the CBA line. In the liver and blood serum, the concentration of urea was determined, in the serum – additionally albumin. It was found that by itself, the dietary load of amino acids did not cause a significant increase in urea synthesis in the liver of mice. However, in animals with a dietary amino acid load after injury, increased urea synthesis was observed until the 7th day of the post-traumatic period, in contrast to animals with injury, but without the addition of amino acids to the diet, in which a high level of urea was noted only on the 3rd day after injuries. Obviously, the additional use of amino acids in the post-traumatic period is a factor that increases the functional metabolic load on the liver.
References:
1. Fabiani R., Naldini G., Chiavarini M. Dietary Patterns in Relation to Low Bone Mineral Density and Fracture Risk: A Systematic Review and Meta-Analysis. Adv. Nutr. 2019;10(2):219-236. https://doi.org/10.1093/advances/nmy073
2. Malafarina V., Reginster J. Y., Cabrerizo S., Bruyère O., Kanis J. A. [et al.]. Nutritional status and nutritional treatment are related to outcomes and mortality in older adults with hip fracture. Nutrients. 2018;10(5):555. https://doi.org/10.3390/nu10050555
3. Schmidt I., Albert J., Ritthaler M., Papastavrou A., Steinmann P. Bone fracture healing within a continuum bone remodelling framework. Comput. Methods Biomech. Biomed. Engin. 2022;25(9):1040-1050. https://doi.org/10.1080/10255842.2021.1998465
4. Handcox J. E., Gutierrez-Naranjo J. M., Salazar L. M., Bullock T. S., Griffin L. P., Zelle B. A. Nutrition and vitamin deficiencies are common in orthopaedic trauma patients. J. Clin. Med. 2021;10(21):5012. https://doi.org/10.3390/jcm10215012
5. Merloz P. Optimization of perioperative management of proximal femoral fracture in the elderly. Orthop. Traumatol. Surg. Res. 2018;104(1S):S25-S30. https://doi.org/10.1016/j.otsr.2017.04.020
6. Meesters D. M., Wijnands K. A. P., Brink P. R. G., Poeze M. Malnutrition and fracture healing: are specific deficiencies in amino acids important in nonunion development? Nutrients. 2018;10(11):1597. https://doi.org/10.3390/nu10111597
7. Ramanathan V., Venugopalan S., Ganapathy D., Ramadoss R., Kumar S. M. [et al.]. Effect of dietary amino acids l-arginine and lysine on implant osseointegration. J. Pharm. Bioallied Sci. 2022;14(Suppl.1):S106-S109. https://doi.org/10.4103/jpbs.jpbs_594_21
8. Roberts J. L., Drissi H. Advances and promises of nutritional influences on natural bone repair. J. Orthop. Res. 2020;38(4):695-707. https://doi.org/10.1002/jor.24527
9. Gholami F., Naghshi S., Samadi M., Rasaei N., Mirzaei K. Dietary acid load and bone health: a systematic review and meta-analysis of observational studies. Front. Nutr. 2022;9:869132. https://doi.org/10.3389/fnut.2022.869132
10. Hew J. J., Parungao R. J., Mooney C. P., Smyth J. K., Kim S. [et al.]. Low-protein diet accelerates wound healing in mice post-acute injury. Burns Trauma. 2021;9:tkab010. https://doi.org/10.1093/burnst/tkab010
11. Jadzic J., Djonic D. Bone loss in chronic liver diseases: Could healthy liver be a requirement for good bone health? World J. Gastroenterol. 2023;29(5):825-833. https://doi.org/10.3748/wjg.v29.i5.825
12. Liu Y., Yao C., Wang Y., Liu X., Xu S., Liang L. Protective Effect of Crocin on Liver Function and Survival in Rats With Traumatic Hemorrhagic Shock. J. Surg. Res. 2021;261:301-309. https://doi.org/10.1016/j.jss.2020.12.027
Keywords: urea synthesis, bone fracture, liver, amino acids, nutrition
Founders:
Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy