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https://doi.org/10.14300/mnnc.2023.18051

Biomarkers of necrotizing enterocolitis through the prism of etiopathogenesis

[Reviews]
Polina Konstantinovna Vinel; Valentina Viktorovna Tsareva; Anton Ivanovich Sinitskiy; Artem Sergeevich Kozhevnikov; Aleksey Vasilievich Sherstobitov; Yury Alekseevich Semenov;

The review analyzes the pathogenetic aspects of using diagnostic markers of necrotizing enterocolitis (NEC). The substantiation of the leading and common tags for various pathological factors depending on the period of the disease in newborns is carried out. Peculiarities of diagnostics, characteristic of different stages of the disease, are considered. Thus, using biomarkers that consider the staging and severity of the course of NEC in newborns will allow targeted interventions on various etiopathogenetic links to prevent disease progression and reduce mortality.

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References:
1. Simakhodsky A. S., Gorelik Yu. V., Gorelik K. D., Ivanov S. L., Lukashova Yu. Mortality of children born on early gestational age: is it the impassable barrier or the reserve for reducing the infants mortality? Voprosy sovremennoj pediatrii. 2020;19(5):340-345. https://doi.org/10.15690/vsp.v19i5.2209
2. Su Y., Xu R. H., Guo L. Y., Chen X. Q., Han W. X. [et al.] Risk factors for necrotizing enterocolitis in neonates: A meta-analysis. Frontiers in pediatrics. 2023;10:2334. https://doi.org/10.3389/fped.2022.1079894
3. Gordon P. V., Swanson J. R. Necrotizing enterocolitis is one disease with many origins and potential means of prevention. Pathophysiology. 2014;21(1):13-19. https://doi.org/10.1016/j.pathophys.2013.11.015
4. Andrews R. E., Coe K. L., Gephart S. M., Quinn M. Clinical presentation and multifactorial pathogenesis of necrotizing enterocolitis in the preterm infant. Advances in Neonatal Care. 2021;21(5):349-355. https://doi.org/10.1097/ANC.0000000000000880
5. Bubberman J. M., Van Zoonen A., Bruggink J. L. M., Van Der Heide M., Berger R. M. F. [et al.] Necrotizing enterocolitis associated with congenital heart disease: a different entity? Journal of pediatric surgery. 2019;54(9):1755-1760. https://doi.org/10.1016/j.jpedsurg.2018.11.012
6. Hackam D. J. Anemia, blood transfusions, and necrotizing enterocolitis in premature infants. Pediatric research.2022;91(6):1317-1319. https://doi.org/10.1038/s41390-022-02007-w
7. Cheng C., He Y., Xiao S., Ai Q., Yu J. The association between enteric viruses and necrotizing enterocolitis. European Journal of Pediatrics. 2021;180:225-232. https://doi.org/10.1007/s00431-020-03746-w
8. Zakharova I. N., Dmitrieva Yu. A. Dietary protein-induced enterocolitis syndrome (FPIES): modern principles of diagnosis and treatment based on the analysis of the provisions of the international consensus. Pediatriya. Appendix to the journal Consilium Medicum. 2018;(1):15-22. https://doi.org/10.26442/2413-8460_2018.1.15-22
9. Yoffe Deri, S., Melamed R., Marks K., Mizrakli Y., Leibovitz E. [et al.] Early versus late-onset necrotizing enterocolitis in very low birth infants in the neonatal intensive care unit. Pediatric Surgery International. 2022;38(2):235-240. https://doi.org/10.1007/s00383-021-05029-3
10. Ng P. C. An update on biomarkers of necrotizing enterocolitis. Seminars in Fetal and Neonatal Medicine. WB Saunders. 2018(23.6):380-386. https://doi.org/10.1016/j.siny.2018.07.006
11. Thomaidou A., Deda O., Begou O., Lioupi A., Kontou A. A. [et al.] Prospective, Case-Control Study of Serum Metabolomics in Neonates with Late-Onset Sepsis and Necrotizing Enterocolitis. Journal of Clinical Medicine.2022;11(18):5270. https://doi.org/10.3390/jcm11185270
12. Sylvester K. G., Kastenberg Z. J., Moss R. L., Enns G. M., Cowan T. M. [et al.] Acylcarnitine profiles reflect metabolic vulnerability for necrotizing enterocolitis in newborns born premature. Journal of pediatrics. 2018;181:80-85. https://doi.org/10.1016/j.jpeds.2016.10.019
13. Veshkurtseva I. M., Akselrov M. A., Minaev S. V., Suprunets S. N., Emelyanova V. A. [et al.] Effect of microbial landscape on the character of antibacterial therapy in newborns with necrotizing enterocolitis. Medical News of North Caucasus. 2020;15(4):492-495. https://doi.org/10.14300/mnnc.2020.15115
14. Gómez-Chaparro Moreno J. L., Rodríguez Torronteras A., Ruiz González M. D., Izquierdo Palomares L., Bonilla Valverde D. [et al.] The β-glucosidase assay: a new diagnostic tool for necrotizing enterocolitis. Sensitivity, specificity, and predictive values. European journal of pediatrics.2016;175:931-941. https://doi.org/10.1007/s00431-016-2724-8
15. Blackwood B. P., Wood D. R., Yuan C. Y., Nicolas J. D., Griffiths A. [et al.] Urinary claudin-2 measurements as a predictor of necrotizing enterocolitis: a pilot study. Journal of Neonatal Surgery. 2015;4(4).
16. Ng E. W., Poon T. C., Lam H. S., Cheung H. M., Ma T. P. [et al.] Gut-associated biomarkers L-FABP, I-FABP, and TFF3 and LIT score for diagnosis of surgical necrotizing enterocolitis in preterm infants. Annals of surgery.2013;258(6):1111-1118. https://doi.org/10.1097/SLA.0b013e318288ea96
17. Cai N., Liao W., Chen Z., Tao M., Chen S. The Mean Platelet Volume Combined with Procalcitonin as an Early Accessible Marker Helps to Predict the Severity of Necrotizing Enterocolitis in Preterm Infants. International Journal of General Medicine. 2022;3789-3795.
18. Coufal S., Kokesova A., Tlaskalova-Hogenova H., Frybova B., Snajdauf J. [et al.] Urinary I-FABP, L-FABP, TFF-3, and SAA can diagnose and predict the disease course in necrotizing enterocolitis at the early stage of disease. Journal of Immunology Research. 2020;1:10. https://doi.org/10.1155/2020/3074313
19. Jawale N., Prideaux M., Prasad M., Miller M., Rastogi S. Plasma citrulline as a biomarker for early diagnosis of necrotizing enterocolitis in preterm infants. American Journal of Perinatology. 2021;38(13):1435-1441. https://doi.org/10.1055/s-0040-1713406
20. Liu T., Zong H., Chen X., Li S., Liu Z. [et al.] Toll-like receptor 4-mediated necroptosis in the development of necrotizing enterocolitis. Pediatric Research. 2022;91(1):73-82. https://doi.org/10.1038/s41390-021-01457-y
21. Guo T., Hu S., Xu W., Zhou J., Chen F. [et al.] Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis. iScience, 2023. https://doi.org/10.1016/j.isci.2023.106882
22. Sinclair T. J., Ye C., Chen Y., Zhang D., Li T. [et al.] Progressive metabolic dysfunction and nutritional vari ability precedes necrotizing enterocolitis. Nutrients.2020;12(5):1275. https://doi.org/10.3390/nu12051275
23. Perrone S., Tataranno M.L., Negro S., Cornacchione S., Longini M. [et al.] May oxidative stress biomarkers in cord blood predict the occurrence of necrotizing enterocolitis in preterm infants? J. Matern. Fetal. Neonatal. Med. 2012;1:128-131. https://doi.org/10.3109/14767058.2012.663197
24. Becker R., Wu G., Galanko J., Chen W., Maynor A. [et al.] Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. J. Pediatr. 2000;137(6):785-793. https://doi.org/10.1067/mpd.2000
25. Zamora S., Amin H., McMillan D., Kubes P., Fick G. [et al.] Plasma L-arginine concentrations in premature infants with necrotizing enterocolitis. J. Pediatr. 1997;131(2):226-232. https://doi.org/10.1016/S0022-3476(97)70158-6
26. Babu S., Prasad M., Miller M., Morrissey M., Bhutada A. [et al.] Use of serum citrulline concentrations from routine newborn screen as a biomarker for necrotizing enterocolitis. Pediatric Surgery International. 2019;35:715-722. https://doi.org/10.1007/s00383-019-04470-9
27. Gurel S., Erel O. The Relevant Relationship Between Umbilical Cord Blood Gas and Acid Base Analysis and Dynamic Thiol (Sh)/Disulphide (S-S) Balance in Neonatal Babies with Different Perinatal Risks and Newborn Diseases. Innov. J. Pediatr. 2020;30(4):e102793. https://doi.org/10.5812/ijp.102793
28. Griffiths V., Al Assaf N., Khan R. Review of claudin proteins as potential biomarkers for necrotizing enterocolitis. Ir. J. Med. Sci. 2021;190(4):1465-1472. https://doi.org/10.1007/s11845-020-02490-2
29. Minaev S. V., Obedin A. N., Kachanov A. V., Annenkov M. V., Tovkan E. A. [et al.] Fast track in the treatment of newborns with necrotizing enterocolitis. Medical News of North Caucasus. 2016;11(2):152-155. https://doi.org/10.14300/mnnc.2016.11023
30. Thuijls G., Derikx J., van Wijck K., Zimmermann L., Degraeuwe P. [et al.] Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis. Ann. Surg. 2010;251(6):1174-1180. https://doi.org/10.1097/SLA.0b013e3181d778c4
31. Surmeli Onay O., Korkmaz A., Yigit S., Yurdakok M. Hypoxic-ischemic enterocolitis: a proposal of a new terminology for early NEC or NEC-like disease in preterm infants, a single-center prospective observational study. Eur. J. Pediatr. 2020;179(4):561-570. https://doi.org/10.1007/s00431-019-03539-w
32. Raffaeli G., Manzoni F., Cortesi V., Cavallaro G., Mosca F. [et al.] Iron homeostasis disruption and oxidative stress in preterm newborns. Nutrients. 2020;12(6):1554. https://doi.org/10.3390/nu12061554
33. Shevtsova A., Gordiienko I., Tkachenko V., Ushakova G. Ischemia-Modified Albumin: Origins and Clinical Implications. Dis. Markers. 2021;2021:9945424. https://doi.org/10.1155/2021/9945424
34. Yakut I., Tayman C., Oztekin O., Namuslu M., Karaca F., Kosus A. Ischemia-modified albumin may be a novel marker for the diagnosis and follow-up of necrotizing enterocolitis. J. Clin. Lab. Anal. 2014;28(3):170-177. https://doi.org/10.1002/jcla.21661
35. ElMeneza S., Okasha A., Abd El-Hafez M., Hussein N. Ischemia-modified albumin as a novel marker for diagnosis of necrotizing enterocolitis in newborn infants. Journal of Pediatric and Neonatal Individualized Medicine (JPNIM).2021;10(2):e100205. https://doi.org/10.7363/100205
36. Shaaban A., Alfqy O., Shaaban H., A-Maqsoud Y., Assar E. Potential Role of Serum Intestinal Fatty Acid-Binding Protein as a Marker for Early Prediction and Diagnosis of Necrotizing Enterocolitis in Preterm Neonates. J. Indian Assoc. Pediatr. Surg. 2021;26(6):393-400. https://doi.org/10.4103/jiaps.JIAPS_218_20
37. Schurink M., Kooi E., Hulzebos C., Kox R., Groen H. [et al.] Intestinal fatty acid-binding protein as a diagnostic marker for complicated and uncomplicated necrotizing enterocolitis: a prospective cohort study. PLoS One.2015;10(3):e0121336. https://doi.org/10.1371/journal.pone.0121336
38. Arisanti D., Wibowo S., Soemarno S. Calprotectin and intestinal fatty acid binding protein (I-FABP) level in preterm neonates with necrotizing enterocolitis. Research Journal of Life Science. 2019;6(1):1-10. https://doi.org/10.21776/ub.rjls.2019.006.01.1
39. Bein A., Eventov-Friedman S., Arbell D., Schwartz B. Intestinal tight junctions are severely altered in NEC preterm neonates. Pediatr. Neonatol. 2018;59(5):464-473. https://doi.org/10.1016/j.pedneo.2017.11.018
40. Lei G., Zhang J., Wang X., Chen M. Plasma D-lactate Levels in Necrotizing Enterocolitis in Premature Infants. Iran J. Pediatr. 2016;26(2):e4403. https://doi.org/10.5812/ijp.4403
41. Benkoe T., Mechtler T., Pones M., Prusa A. Klebermass-Schrehof K. [et al.] The plasma activities of lysosomal enzymes in infants with necrotizing enterocolitis: new promising class of biomarkers? Clin. Chim. Acta.2015;438:279-283. https://doi.org/10.1016/j.cca.2014.08.043
42. Qu Y., Xu W., Han J., Zhou W., Wu H. Diagnostic value of fecal calprotectin in necrotizing enterocolitis: A meta-analysis. Early Hum. Dev. 2020;151:105170. https://doi.org/10.1016/j.earlhumdev.2020.105170
43. Evennett N., Cerigioni E., Hall N., Pierro A., Eaton S. Smooth muscle actin as a novel serologic marker of severe intestinal damage in rat intestinal ischemia-reperfusion and human necrotising enterocolitis. J. Surg. Res.2014;191(2):323-330. https://doi.org/10.1016/j.jss.2014.04.020
44. Richir M., Siroen M., van Elburg R., Fetter W., Quik F. [et al.] Low plasma concentrations of arginine and asymmetric dimethylarginine in premature infants with necrotizing enterocolitis. Br. J. Nutr. 2007;97(5):906-911. https://doi.org/10.1017/S0007114507669268
45. Celik I., Demirel G., Canpolat F., Dilmen U. Reduced plasma citrulline levels in low birth weight infants with necrotizing enterocolitis. J. Clin. Lab. Anal. 2013;27(4):328-332. https://doi.org/10.1002/jcla.21607
46. Minaev S. V., Khodzhayan A. B., Tsutsieva V. V., Minaev N. V., Obedin A. N. [et al.] Modern approaches to studying the quality of life in children. Medical News of North Caucasus. 2010;1:77-83.
47. Feenstra F., Kuik S., Derikx J., Heiner-Fokkema M., Kooi E. [et al.] Plasma citrulline during the first 48 h after onset of necrotizing enterocolitis in preterm infants. J. Pediatr. Surg. 2021;56(3):476-482. https://doi.org/10.1016/j.jpedsurg.2020.11.020
48. Zhu H., Lin Y., Liu Y. miR-34a increases inflammation and oxidative stress levels in patients with necrotizing enterocolitis by downregulating SIRT1 expression. Mol. Med. Rep. 2021;24(3):664. https://doi.org/10.3892/mmr.2021.12303
49. Kirgizov I. V., Minaev S. V. The ultrasonic way of the intraoperative assess of the resection volume of colon in children with chronic constipation. Medical News of North Caucasus. 2014;9(2):125-128. https://doi.org/10.14300/mnnc.2014.09035
50. Zhou C., Li L., Feng X., Wang D., Liu Y. [et al.] Serum galectin-3 level as a marker for diagnosis and prognosis of neonatal necrotising enterocolitis: a cohort study. Am. J. Transl. Res. 2021;13(5):5731-5737.
51. Caplan M. C. The Role of Platelet-Activating Factor in the Pathogenesis of Necrotizing Enterocolitis. CRC Press, 2021

Keywords: necrotizing enterocolitis, biomarkers, children