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https://doi.org/10.14300/mnnc.2023.18029

Characteristics of iron deficiency in children with celiac disease

[Original research] [Pediatrics]
Tatyana Andreevna Ivenskaya; Leonid Klimov; Victoria Kuryaninova; Irina Zakharova; Anastasiya Yagupova; Lyubov Kochneva; Elizaveta Andreevna Cherkasova; Valeria Sergeevna Aznauryan;

The iron deficiency (ID) structure was estimated in 235 children with celiac disease aged eight months to 18 years. The patients included in the study were divided into three groups: group I included 64 (27.2 %) children without ID, group II – 106 (45.1 %) children with latent iron deficiency (LID), and group III – 65 (27.7 %) with iron deficiency anemia (IDA). In the period of manifestation of celiac disease, ID conditions were diagnosed in 72.8 % of cases. At the same time, LID dominated the structure of ID forms in all age groups. It was found that in children with celiac disease complicated by IDA, there was a lag in the pace of physical development, as well as more pronounced gastrointestinal symptoms: vomiting was noted more often (p=0.022), bloating (p=0.027) and diarrhea (p=0.018), than in the group I. Total atrophy of the small intestine mucosa villus predominates in 87.7 % of patients with IDA. Thus, specialized laboratory and instrumental methods of diagnosing celiac disease in children should include a detailed analysis of ID.

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Keywords: iron deficiency anemia, atrophy of the small intestine mucosa, celiac disease, children