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рН-sensitive dressing material in monitoring the wound process

[Experimental medicine]
Arsen Grigoryan; Alexander Bezhin; Tatyana Pankrusheva; Lyudmila Zhilyaeva; Sergey Anatolyevich Efanov; Larisa Vasilyevna Atrepyeva;

There was developed the cellulose material that can changes the color in contact with a biological fluid. An analysis of 128 bacteriological cultures of wound discharge with fixation of the pH of the wound in patients with purulent wounds was carried out, in 68 cases, growth of Staphylococcus epidermidis was detected. In the experiment, the pH of the wound and the degree of contamination were studied, and it was found the positive (direct) correlation between them. In addition, change in the color of the dressing was recorded after contact with the wound surface. Thus, without removing the dressing, medical personnel can judge the level of acidity in the wound and draw appropriate conclusions about the need to use antimicrobial drugs, the need to change the dressing, and to determinate the risk of clean wound infection.

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References:
1. Burnham J. P., Kollef M. H. Treatment of severe skin and soft tissue infections: a review. Curr. Opin. Infect. Dis. 2018;31(2):113-119. https://doi.org/10.1097/QCO.0000000000000431
2. Golan Y. Current Treatment Options for Acute Skin and Skin-structure Infections. Clin. Infect. Dis. 2019;68(3):206-212. https://doi.org/10.1093/cid/ciz004
3. Grigoryan A. Yu., Bezhin A. I., Pankrusheva T. A., Sukovatykh B. S., Chekmareva M. S., Zhilyaeva L. V. Multicomponent wound coating in treatment of an experimental, purulent wound. Bulletenʹ sibirskoj mediciny. – Bulletin of Siberian Medicine. 2019;18(3):29-36. (In Russ.). https://doi.org/10.20538/1682-0363-2019-3-29-36
4. Balin V. N., Karshiyev H. K., Muzykin M. I., Iordanishvili A. K. Endogenic intoxication in various methods of managing widespread phlegmons (pre-clinical trial). Kurskij nauchno-prakticheskij vestnik «Chelovek i ego zdorov’e». – Kursk Scientific and Practical Bulletin «Man and His Health». 2017;(1):77-80. (In Russ.). https://doi.org/10.21626/vestnik/2017-1/14
5. Katorkin S. E., Bystrov S. A., Lisin O. E., Rozanova A. A., Bezborodov A. I. Evaluation of the efficacy of modern wound care dressings in the complex treatment of purulent wounds. Ambulatornaya khirurgiya. – Ambulatory Surgery. 2019;(1-2):146-152. (In Russ.). https://doi.org/10.21518/1995-1477-2019-1-2-146-152
6. Shukla S. K., Sharma A. K., Gupta V., Yashavarddhan M. H. Pharmacological control of inflammation in wound healing. J. Tissue Viability. 2019;28:218-222. https://doi.org/10.1016/j.jtv.2019.09.002
7. Chen J., Andler S. M., Goddard J. M., Nugen S. R., Rotello V. M. Integrating recognition elements with nanomaterials for bacteria sensing. Chem. Soc. Rev. 2017;46:1272-1283. https://doi.org/10.1039/C6CS00313C
8. Gupta A., Mumtaz S., Li C. H., Hussain I., Rotello V. M. Combatting antibiotic-resistant bacteria using nanomateri als. Chem. Soc. Rev. 2019;48:415-427. https://doi.org/10.1039/C7CS00748E
9. Ji H., Dong K., Yan Z., Ding C., Chen Z. [et al.]. Bacterial hyaluronidase self-triggered prodrug release for chemophotothermal synergistic treatment of bacterial infection. Small. 2016;12:6200-6206. https://doi.org/10.1002/smll.201601729
10. Wang X. D., Meier R. J., Wolfbeis O. S. Fluorescent pHsensitive nanoparticles in an agarose matrix for imaging of bacterial growth and metabolism. Angew. Chem. Int. Ed.2013;52(1):406-409. https://doi.org/10.1002/anie.201205715
11. Yan Z., Shi P., Ren J., Qu X. A. Sense-and-treat hydrogel used for treatment of bacterial infection on the solid matrix. Small. 2015;11:5540-5544. https://doi.org/10.1002/smll.201501958
12. Harding K., Chadwick P., Jeffery S. L. A., Gray D., Lindsay E. [et al.]. Major concerns regarding the generic product specification for wound care. J. Wound Care.2019;28(8):497. https://doi.org/10.12968/jowc.2019.28.8.497

Keywords: wound pH, wound process, purulent wound, flexible pH-sensitive systems, pH-sensitive dressing material


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Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy