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EBSCO

https://doi.org/10.14300/mnnc.2022.17099

Melatonin and vitamin D3 are induce the expression of endogenous beta-defensin-1 in rats

[Experimental medicine]
Albert Bolatchiev;

The effect of melatonin (10 mg/kg), cholecalciferol (5000 μg/kg), and montelukast (10 mg/kg) on the serum level of the endogenous antimicrobial peptide, beta-defensin-1 (BD-1), was studied for the first time in rats. The study included 32 Wistar rats (male, weighing 180–200 g) – 8 rats in each group. The drugs were administered daily, once for three days; controls received sterile saline. On the fourth day, blood was taken for enzyme immunoassay. In the control group, the level of BD-1 was 295 (292.9–315.4) pg/ml (hereinafter, the values are presented as a median; in brackets, the first and third quartiles). In comparison with the group, received montelukast, there were no significant differences with the control – the level of BD-1 was 355.3 (329.8–374.5) pg/ml. It was shown that the introduction of melatonin and cholecalciferol (vitamin D3) significantly increases the level of endogenous BD-1: 453 (401.3–479) pg/ml and 533.6 (495–553.5) pg/ml, respectively. The results obtained open up new opportunities for creating a new class of low molecular weight drugs – inducers of endogenous antimicrobial peptides.

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References:
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Keywords: antimicrobial peptides, defensins, melatonin, cholecalciferol