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https://doi.org/10.14300/mnnc.2022.17087

Features of respiratory inflammation in patients with bronchial asthma and comorbid gastroesophageal reflux disease

[Original research] [Internal diseases]
Elena Vitalievna Gorban; Vitaly V. Gorban; Olesya Vladimirovna Svistun;

The correlation of indicators of oxidative metabolism (in terms of blood and oral fluid) and clinical and functional changes in patients with bronchial asthma (BA) with comorbid gastroesophageal reflux disease (GERD) – 30 patients aged 51.5±2.5 years was studied. The functions of external respiration (FVD), allergen-specific IgE, C-reactive protein (CRP), daily pH-metry of the esophagus, esophagogastroduodenoscopy, assessment of enzymatic and non-enzymatic antioxidant activity in erythrocytes and oral fluid and free radical processes in the blood were studied. A decrease in antioxidant protection associated with age, CRP value and polymorbidity was revealed. The body mass index (BMI) and the frequency of dyspnea were directly correlated with the concentration of CRP. At low CRP values, there was a more significant increase in forced vital capacity after the test with berodual. In erosive GERD compared with non-erosive GERD, the compensatory antioxidant response of saliva and blood was more pronounced. Acid gastroesophageal reflux (GER) was directly correlated with age, BMI, and a decrease in blood antioxidant activity. The activity of respiratory inflammation in asthma depended on the stage of comorbid GERD and was accompanied by clinical symptoms and impairments to FVD associated with a discrete imbalance of proinflammatory and antioxidant enzymes.

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Keywords: oxidative inflammation, bronchial asthma, gastroesophageal reflux disease, respiratory function