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Dynamics of soluble selectins during of therapy of non-alcoholic fatty liver disease

[Original research] [Internal diseases]
Alexandr Yagoda; Pavel Koroy; Yuliya Alexandrovna  Kravchenko; Vijaya Sarithala;

The levels of E-, P- and L-selectins in blood were studied during therapy in 42 patients with non-alcoholic fatty liver disease (NAFLD). Patients were divided into three groups. In the first group (17 patients), the hepatoprotective agent was combined with pentoxifylline. In the second group (10 patients) combination of hepatoprotective agent and metformin was applied. In the third group (15 patients), only a hepatoprotective agent (Phosphogliv forte) was prescribed. When using both combined therapy regimens, there could be a decrease in the concentration of E- and P-selectins in blood with normalization of P-selectin levels. Monotherapy with Phosphogliv forte reduced plasma levels of E- and P-selectins, which did not reach control values. In cases of biochemical remission of NAFLD (normalization of aspartic and alanine aminotransferases), a decrease in the concentration of E- and P-selectins in blood was noted. At the same time, levels of P-selectin reached normal values. In patients with preservation of increased activity of aspartic or alanine aminotransferases in dynamics of treatment, only parameters of P-selectin decreased. Thus, against the background of NAFLD therapy, there is a positive dynamics of soluble selectins, which is more pronounced in cases of combined treatment regimens.


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Keywords: non-alcoholic fatty liver disease, treatment, selectins, pentoxifylline, metformin, phosphogliv forte

Stavropol State Medical Academy
Pyatigorsk State Research Institute of Balneotherapeutics
Pyatigorsk State Pharmaceutical Academy