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https://doi.org/10.14300/mnnc.2022.17010

Prediction of the development of infectious complications with pancronecrosis

[Surgery]
Enver Baychorov; Vladimir Baturin; Sergeevich Ganja Nikolay; Ramazanovich Bayramukov Rasul; Shamil Salpagarov; Oleg Zinchenko; Vakhtang Gobejishvili;

Diagnosis, prevention and treatment of infected pancreatic necrosis is a debatable and not fully resolved problem of pancreatology. The traditional laboratory and instrumental diagnostics used today makes it possible to establish the diagnosis of infected pancreatic necrosis, to identify its complications, as a rule, at the later stages of the purulent-inflammatory process development, which does not allow timely adjustment of treatment tactics.

The concentration of the Ubiquitin Protein Ligase E3 enzyme in the blood plasma of patients with acute pancreatitis was studied, the severity of the patients’ condition was assessed using the LODS scale. It was determined the correlation between the form of pancreatic necrosis and the increasing of this enzyme concentration in the dynamics of the disease. An increase in the level of Ubiquitin Protein Ligase E3 indicates the transition of SPN to IPN.

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Keywords: infected pancreatic necrosis, severity of course, prognosis, diagnosis, Ubiquitin Protein Ligase E3