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https://doi.org/10.14300/mnnc.2021.16095

The role of mechanotransduction in the activation of physiological remodeling histione

[Experimental medicine]
Sergey Sirak; Maria Olegovna Didenko; Alla Sirak; Elizaveta Evgenievna Shchetinina; Ekaterina Sergeevna Sirak; Gregory Petrosyan; Margarita Alekseevna Zhuravel; Evgeny Shchetinin;

The article presents the results of a study of the effect of chewing loads on the process of bone remodeling in experimental peri-implantitis in sheep. It was found that in the period of 1–2 months, chewing loads are not able to significantly improve the qualitative characteristics of the regenerate, whereas, from 3 months after the start of the experimental study, the most significant increase in the number of microcirculatory vessels and osteoblastic differentiation cells was noted. The leading role in the activation of the physiological remodeling histione of the jaw bone is played by functional loads for a period of 3 and 7 months, which is manifested in the rate of formation of young reticulofibrous and lamellar bone tissue around the dental implant, which is faster in speed and volume.

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Keywords: mechanotransduction, remodeling, histion, bone tissue, jaw