• Main page
• About the journal
• Editorial board
• Subscription
• Information for contributors
• Editorial and Peer Review
• Issues archive
• Authors
• Articles
  • By alphabet
  • By category
• Blogs and comments

The journal is included into The list of leading scientific periodicals.

The journal is included into VINITI database and is registered in Electronic scientific library.

The journal is indexed by SCOPUS, Ulrich's International Periodicals Directory.

EBSCO

https://doi.org/10.14300/mnnc.2021.16087

Diagnosis and treatment of acute poisoning with 1.4-butanediol complicated by delirium

[Psychiatry]
Andrey Georgievich Sinenchenko; Alexey Lodyagin; Bair Vasilievich Batotsyrenov;

Examination of 40 male patients aged 20 to 45 (32.7±1.1) years with 1.4-butanediol poisoning complicated by delirium revealed the predominance of mixed changes in the acid-base state in the form of respiratory acidosis and metabolic lactic acidosis. The use of Cytoflavin solution (40 ml per day) was accompanied by a significant change in the acid-base state, a decrease in lactate in capillary blood by the 3rd day of therapy from 3.9 to 2.8 mmol/l, a decrease in the severity of delirious symptoms by the 5th day from 21.2 to 17.3 points, on the DRS-R-98 scale, an increase in the oxygen consumption and the release of carbon dioxide by the 7th day by 21.08 and 7.3 %, in comparison with the control group. Thus, Cytoflavin, containing succinic acid in its composition in the form of Na, N-methylglucammonium succinate, is able to compensate metabolic lactate acidosis at an earlier date, stabilize the acid-base state by increasing oxygen consumption and activating of aerobic oxidation processes.

Download

References:
1. Rengel K. F., Pandharipande P. P., Hughes C. G. Postoperative delirium. Presse. Med. 2018;47(4):53-64. https://doi.org/10.1016/j.lpm.2018.03.012
2. Hshieh T. T., Inouye S. K., Oh E. S. Delirium in the Elderly. Psychiatr. Clin. North Am. 2018;41(1):1-17. https://doi.org/10.1016/j.psc.2017.10.001
3. Mahlaj A. V., Pasechnik I. N., Gubajdullin R. R. Onegin M. A. Sedation strategies for patients with postoperative delirium. Anesteziologija i reanimatologija. – Anesthesiology and Reanimatology. 2017;62(2):152-157. (In Russ.). https://doi.org/10.18821/0201-7563-2017-62-2-152-157
4. Hübscher A., Isenmann S. Delir: Konzepte, Ätiologie und klinisches Management [Delirium: Concepts, Etiology, and Clinical Management]. Fortschr. Neurol. Psychiatr. 2016;84(4):233-244. https://doi.org/10.1055/s-0042-104502
5. Ploshhenko Ju. A., Kligunenko E. N. Current guidelines for the prevention and treatment of postoperative delirium in intensive care units. Medicina neotlozhnyh sostojanij. – Emergency medicine. 2018;6(93):109-116. (In Russ.). https://doi.org/10.22141/2224-0586.6.93.2018.147653
6. Lev-Ran S., Le Strat Y., Imtiaz S., Rehm J., Le Foll B. Gender differences in prevalence of substance use disorders among individuals with lifetime exposure to substances: results from a large representative sample. Am. J. Addict. 2013;22(1):7-13. https://doi.org/10.1111/j.1521-0391.2013.00321.х
7. Gollmann M., Frimlova G., Just S., Liebetrau G., Prasa D. [et al.]. Substanzmissbrauch – Entwicklung des Vergiftungsgeschehens im Einzugsbereich des Giftnotrufes Erfurt 2002–2016 [Substance Abuse Poisoning Reported to the Poisons Information Centre Erfurt from 2002 to 2016]. Gesundheitswesen. 2019;81(5):397-404. https://doi.org/doi:10.1055/a-0592-6674
8. Hassan Z., Bosch O. G., Singh D., Narayanan S., Kasinather B. V. [et al.]. Novel Psychoactive Substances-Recent Progress on Neuropharmacological Mechanisms of Action for Selected Drugs. Front. Psychiatry. 2017;18(8):152. https://doi.org/10.3389/fpsyt.2017.00152
9. Zawilska J. B., Andrzejczak D. Next generation of novel psychoactive substances on the horizon – A complex problem to face. Drug Alcohol. Depend. 2015;1(157):1-17. https://doi.org/10.1016/j.drugalcdep
10. Bulut H. A New Psychoactive Substance, Gamma Hydroxybutyrate (GHB): A Case Report. Noro Psikiyatr. Ars. 2019;56(3):229-231. https://doi.org/10.29399/npa.23198 11. Busardò F. P, Vergallo G. M., Plazzi G. GHB Pharmacology and Toxicology: From Metabolism and Pharmacokinetics to Applications: In Clinical and Forensic Toxicology. Curr. Drug Metab. 2018;19(13):1054-1055. https://doi.org/10.2174/138920021913181029122146
12. Sinenchenko A. G., Lodjagin A. N., Batocyrenov B. V., Glushkov S. I. Development of delirious syndrome in acute poisoning with 1,4-butanediol. Zhurnal nevrologii i psihiatrii im. S. S. Korsakova. – S. S. Korsakov Journal of Neurology and Psychiatry. 2018;118(12):53-56. (In Russ.). https://doi.org/10.17116/jnevro201811812153
13. Kamal R. M., van Noorden M. S., Franzek E., Dijkstra B. A., Loonen A. J. [et al.]. The Neurobiological Mechanisms of Gamma-Hydroxybutyrate Dependence and Withdrawal and Their Clinical Relevance: A Review. Neuropsychobiology. 2016;73(2):65-80. https://doi.org/10.1159/000443173
14. Vasil’ev S. A., Shilov V. V., Barabanov P. A., Sencov V. G., Jacinjuk B. B. Acute poisoning with synthetic drugs. Obshhaja reanimatologija. – General resuscitation. 2018;14(1):23-28. (In Russ.). https://doi.org/10.15360/1813-9779-2018-1-23-28
15. Lebedeva E. A., Skoblo M. L., Adlejba L. Z., Lohmatova V. V. Options for managing postoperative delirium in older patients. Uspehi gerontologii. – Advances in gerontology. 2019;32(1-2):128-132. (In Russ.). https://doi.org/10.15360/1813-9779-2018-1-23-28
16. Buzanov D. V., Afanas’ev V. V., Miroshnichenko A. G., Basharin V. A., Petrova N. V. [et al.]. The use of a combination of molixan and cytoflavin for the treatment of alcoholic coma in an inpatient emergency department. Skoraja medicinskaja pomoshh’. – Emergency. 2018;19(2):28-33. (In Russ.). https://doi.org/10.24884/2072-6716-2018-19-2-28-33
17. Gerrity R. S., Pizon A. F., King A. M., Katz K. D., Menke N. B. A Patient With Alcoholic Ketoacidosis and Profound Lactemia. J. Emerg. Med. 2016;51(4):447-449. https://doi.org/doi:10.1016/j.jemermed.2015.05.048
18. Seheult J., Fitzpatrick G., Boran G. Lactic acidosis: an update. Clin. Chem. Lab. Med. 2017;55(3):322-333. https://doi.org/10.1515/cclm-2016-0438
19. Chutko L. S., Surushkina S. Ju., Jakovenko E. A., Rozhkova A. V., Anisimova T. I. [et al.]. Effectiveness of cytofalavin in the treatment of burnout syndrome. Zhurnal nevrologii i psihiatrii im. S. S. Korsakova. – S. S. Korsakov Journal of Neurology and Psychiatry. 2015;115(10):66-70. (In Russ.). https://doi.org/10.17116/jnevro201511510166-70
20. Cummins E. P., Strowitzki M. J., Taylor C. T. Mechanisms and Consequences of Oxygen and Carbon Dioxide Sensing in Mammals. Physiol. Rev. 2020;100(1):463-488. https://doi.org/10.1152/physrev.00003.2019

Keywords: cytoflavin, hypoxia, delirium, 1.4-butanediol, metabolic lactate acidosis, oxygen consumption, succinate