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Pathobiochemical changes in the histological structure of kidneys with experimental hypervitaminosis D

[Experimental medicine]
Tatiana Bondar; Kirill Svetlitskiy; Yulia Sergeevna Svetlitskaya; Valentina Botasheva;

This study focused on the nature and degree of pathobiochemical changes in kidney tissues from the post lactation period of female rats and their offspring at different ages after exposure to hypervitaminosis D. The pathobiochemical cascade from hypervitaminosis D involved excessive calcium accumulation and was characterized by self-damage to cells and the development of hypoxia during gestation and lactation and in the post-lactation period in rats and their offspring. Hypervitaminosis D produced vascular disorders (plethora of vessels of the kidney, stasis and interstitial edema) leading to increased epithelial cell size and narrowing of the lumen of tubules. These disorders were combined with hyaline-droplet protein dystrophy of the convoluted tubules and fatty degeneration of the epithelium of collecting ducts. There were also multiple foci of hypereosinophilia and areas of calcification located in the vessel walls, glomeruli and tubules of kidneys.

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Keywords: hypervitaminosis D, calcium, hypoxia, kidneys, experiment, epithelial cells


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