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https://doi.org/10.14300/mnnc.2021.16012

Modulation of neuroplasticity using optogenetic stimulation of the dorsal hippocampus

[Experimental medicine]
Irina Ivanovna Fomochkina; Tigran Romaevich Petrosyan; Anatoly Vladimirovich Kubyshkin; Vitalina Igorevna Petrenko; Leia Evgenievna Sorokina; Evgeniya Yurievna Zyablitskaya; Server Iskandarovich Khalilov; Biryukova Elena;

Morphological and functional analysis was performed after optogenetic stimulation of dorsal hippocampal neurons in transgenic mice, performed after stereotactic implementation of a fiber-optic neurointerface. As a result, prolonged blue light stimulation with a wavelength of 470 nm for 8 weeks provided activation of the growth of myelinated processes, an increase in the density of the dorsal hippocampus and cerebral cortex, as well as an improvement in cognitive functions in mice of the experimental group were revealed.

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Keywords: optogenetics, neurointerface, optogenetic stimulation, neuroglia, modulation of neurons, neurodegenerative diseases, stereotaxis, synaptic activity, dorsal hippocampus, neuroplasticity